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PLPP1

Phospholipid phosphatase 1 is a protein in humans that is encoded by PLPP1 gene. Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.

PLPP1 Antibodies

PLPP1 for Homo sapiens (Human)

PLPP1 Proteins

PLPP1 Proteins for Sus scrofa (Pig)

PLPP1 Proteins for Homo sapiens (Human)

PLPP1 Proteins for Rattus norvegicus (Rat)

PLPP1 Proteins for Cavia porcellus (Guinea pig)

PLPP1 Proteins for Mus musculus (Mouse)



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