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ITM2B

ITM2B,全稱為整合膜蛋白2B,常用別名是BRI2。它是一種跨膜蛋白,在人體多種組織中分布,其中神經系統的神經元是其主要表達場所。這種蛋白能與淀粉樣前體蛋白等分子結合,調控這些蛋白的加工過程,避免產生對神經細胞有毒性的異常片段,維持神經細胞正常功能。
當ITM2B基因發生突變時,BRI2蛋白功能異常,無法有效調控相關蛋白,進而引發家族性英國型癡呆和家族性丹麥型癡呆兩種罕見神經退行性疾病,患者會出現認知下降、運動障礙等癥狀,與阿爾茨海默病部分表現相似。藥物研發方面,實驗室正探索通過小分子或肽類調節BRI2活性,以改善相關蛋白代謝異常,為這類疾病治療提供新思路,但目前研究多處于早期階段。

熱銷產品

ITM2B Antibody (CSB-PA011904LA01HU)

驗證數據

CSB-PA011904LA01HU

IHC image of CSB-PA011904LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA011904LA01HU

IHC image of CSB-PA011904LA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA011904LA01HU

Immunofluorescence staining of Hela cells with CSB-PA011904LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ITM2B Antibodies

ITM2B for Homo sapiens (Human)

ITM2B Proteins

ITM2B Proteins for Homo sapiens (Human)



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