EDN3
EDN3，全稱為內(nèi)皮素3，常被簡稱為ET-3。這種蛋白是人體內(nèi)一類關(guān)鍵的活性分子，能與特定受體結(jié)合，在胚胎發(fā)育過程中扮演重要角色——比如助力腸道內(nèi)神經(jīng)細(xì)胞群的正常形成，以及皮膚、眼睛等部位色素細(xì)胞的分化與分布。若EDN3功能出現(xiàn)異常，可能引發(fā)一些先天性疾病：部分先天性巨結(jié)腸患者，正是因為腸道神經(jīng)細(xì)胞發(fā)育不全，與EDN3相關(guān)的分子互動出現(xiàn)問題所致；此外，它的紊亂也可能和皮膚色素沉著異常有關(guān)。在藥物研發(fā)領(lǐng)域，目前有團(tuán)隊在探索針對EDN3相關(guān)分子路徑的干預(yù)方法，希望為這類先天性疾病提供新的治療方向，不過多數(shù)研究仍處于實驗室或早期臨床試驗階段，尚未有成熟藥物投入臨床使用。
熱銷產(chǎn)品
Recombinant Human Endothelin-3 (EDN3) (CSB-YP007402HUf3)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA111567(EDN3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA111567(EDN3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
EDN3 Antibodies
EDN3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007402GA01HU | EDN3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA111567 | EDN3 Antibody | Human | ELISA,IHC |
| CSB-PA151323 | EDN3 Antibody | Human | ELISA,IHC |
| CSB-PA066402 | EDN3 Antibody | Human | ELISA,IHC |
EDN3 Proteins
EDN3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007402HU CSB-EP007402HU CSB-BP007402HU CSB-MP007402HU CSB-EP007402HU-B |
Recombinant Human Endothelin-3 (EDN3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP007402HUf3 | Recombinant Human Endothelin-3 (EDN3) | Yeast |
