DDX53
DDX53，全稱為DEAD-box解旋酶53，常見別名包括HEL117。這種蛋白能解開RNA的雙鏈結(jié)構(gòu)，在細(xì)胞里參與RNA的加工和轉(zhuǎn)運(yùn)，幫著維持基因表達(dá)的正常節(jié)奏。一旦DDX53的表達(dá)量或功能出了問題，可能會(huì)打亂細(xì)胞內(nèi)的分子平衡，和一些疾病掛上鉤。比如在前列腺癌、非小細(xì)胞肺癌患者的組織樣本里，它的含量往往比正常細(xì)胞高很多，可能助推腫瘤細(xì)胞生長(zhǎng)和擴(kuò)散，算是這些癌癥里一個(gè)潛在的標(biāo)記物。現(xiàn)在針對(duì)它的藥物研究還在早期，科學(xué)家們?cè)囍_發(fā)能抑制它功能的小分子化合物，希望通過瞄準(zhǔn)它阻止腫瘤發(fā)展。
熱銷產(chǎn)品
Recombinant Human Probable ATP-dependent RNA helicase DDX53 (DDX53) (CSB-EP773024HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP773024HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DDX53.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP773024HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DDX53.
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA801951(DDX53 Antibody) at dilution 1/75, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA801951(DDX53 Antibody) at dilution 1/75, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA801951(DDX53 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
DDX53 Antibodies
DDX53 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA801951 | DDX53 Antibody | Human | ELISA,WB,IHC |
| CSB-PA343705 | DDX53 Antibody | Human | ELISA,WB,IHC |
DDX53 Proteins
DDX53 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP773024HU CSB-BP773024HU CSB-MP773024HU CSB-EP773024HU-B |
Recombinant Human Probable ATP-dependent RNA helicase DDX53 (DDX53) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP773024HU | Recombinant Human Probable ATP-dependent RNA helicase DDX53 (DDX53) | E.coli |
