GPR20 (US10906974 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA860774MB1HU
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規格:¥83486
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其他:
產品詳情
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產品描述:GPR20 (US10906974 Biosimilar Antibody) 重組單克隆抗體是一種針對G蛋白偶聯受體20(GPR20),其別名為G protein coupled receptor 20 antibody、G-protein coupled receptor 20 antibody、Gpr20 antibody或GPR20_HUMAN antibody。該抗體以重組人GPR20蛋白制備,具有高度特異性,可與人類及食蟹猴(Macaca fascicularis)的GPR20蛋白發生特異性結合,為相關研究提供了可靠的檢測工具。 在藥物研發領域,以 G 蛋白偶聯受體 GPR20 為靶點的配體、拮抗劑或激動劑,有望用于治療因 GPR20 異常表達或激活引發的相關疾病。GPR20 在多種生理和病理過程中發揮作用,其功能異常與部分神經系統疾病、代謝性疾病及腫瘤的發生發展密切相關。這類靶向藥物可通過特異性調節 GPR20 的活性,達到改善疾病癥狀、延緩病情進展的效果,為相關疾病的治療方案優化提供潛在方向。目前,針對 GPR20 的靶向藥物多處于臨床前或早期臨床試驗階段,尚未獲批臨床應用。 GPR20重組單克隆抗體可廣泛應用于分子生物學、細胞生物學等研究領域。例如,在實驗中,該抗體能夠特異性檢測GPR20蛋白的表達水平和亞細胞定位,助力研究人員揭示GPR20在細胞信號轉導、組織發育及疾病模型中的功能。其對人類和食蟹猴的種屬反應性,也為跨物種研究提供了便利,有助于更全面地理解GPR20的生物學功能及其在不同物種間的保守性與差異性。
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Uniprot No.:
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基因名:
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別名:G protein coupled receptor 20 antibody; G-protein coupled receptor 20 antibody; Gpr20 antibody; GPR20_HUMAN antibody
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反應種屬:Human
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免疫原:Recombinant Human GPR20 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:In stock
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產品
靶點詳情
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功能:Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
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基因功能參考文獻:
- GPR20 constitutively activates G(i) proteins without ligand stimulation PMID: 18347022
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family
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組織特異性:Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus.
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數據庫鏈接:
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