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  4. GFRA3 (Nadecnemab Biosimilar) Recombinant Monoclonal Antibody

GFRA3 (Nadecnemab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA009381MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    REGN5069 research-grade biosimilar; REGN 5069 research-grade biosimilar; REGN-5069 research-grade biosimilar; GFRA3 antibody; UNQ339/PRO538/PRO3664 antibody;GDNF family receptor alpha-3 antibody; GDNF receptor alpha-3 antibody; GDNFR-alpha-3 antibody; GFR-alpha-3 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GFRA3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
  • 基因功能參考文獻：
    1. increased GFRalpha3 expression is significantly correlated with poor prognosis of patients with urothelial carcinoma PMID: 28651425
    2. Mir-34a directly regulates GFRA3 via its coding region.GFRA3 is crucial for breast cancer growth. PMID: 28356515
    3. The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance. PMID: 26984265
    4. The lack of expression of the RET/GFRA system could be related to the cell mislocation and deregulated growth of craniopharyngiomas. PMID: 22031517
    5. Artemin and GFRalpha3 expressions may play an important role in perineural invasion of pancreatic carcinoma. PMID: 19304517
    6. 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3 was reported. PMID: 16765900
    7. In the human digestive and reproductive systems, a subset of epithelial cells exhibited GFRalpha3- and RET-like staining, suggesting co-localization. PMID: 16773224

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    GDNFR family
  • 組織特異性：
    Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non
  • 數據庫鏈接：

    HGNC: 4245

    OMIM: 605710

    KEGG: hsa:2676

    STRING: 9606.ENSP00000274721

    UniGene: Hs.58042



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