Recombinant Bovine Alpha-synuclein (SNCA)

中文名稱：

牛SNCA重組蛋白
貨號(hào)：

CSB-YP659673BO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

牛SNCA重組蛋白
貨號(hào)：

CSB-EP659673BO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

牛SNCA重組蛋白
貨號(hào)：

CSB-EP659673BO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛SNCA重組蛋白
貨號(hào)：

CSB-BP659673BO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

牛SNCA重組蛋白
貨號(hào)：

CSB-MP659673BO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SNCA
Uniprot No.：

Q3T0G8
別名：

SNCA; Alpha-synuclein
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-140
氨基酸序列

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GRTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGEAV VTGVTAVAQK TVEGAGSIAA ATGFGKKDHM GKGEEGASQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
基因功能參考文獻(xiàn)：
1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 [ANXB12] PMID: 21953452
2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses. PMID: 12932858
亞細(xì)胞定位：

Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted.
蛋白家族：

Synuclein family
數(shù)據(jù)庫鏈接：

KEGG: bta:282857

STRING: 9913.ENSBTAP00000021300

UniGene: Bt.12770