VPS18
VPS18，別名PEP3，在多種組織中廣泛表達，尤其在骨髓、腎臟等組織中表達量較高。VPS18的作用機制涉及其作為CORVET和HOPS復(fù)合體的核心亞基，這兩個復(fù)合體參與介導(dǎo)內(nèi)膜運輸過程，特別是與晚期內(nèi)體/溶酶體相關(guān)，可能介導(dǎo)內(nèi)體/溶酶體途徑中的囊泡運輸步驟。VPS18對于維持細胞內(nèi)蛋白質(zhì)的正確分選和運輸至關(guān)重要，其功能異常可能與某些遺傳性疾病相關(guān)，如Hermansky-Pudlak綜合征。VPS18還參與調(diào)控神經(jīng)細胞存活、遷移和樹突發(fā)育等重要生理功能，對于研究人類神經(jīng)退行性疾病的診斷和防治新策略提供了新的理論依據(jù)和思路。
熱銷產(chǎn)品
VPS18 Antibody (CSB-PA882173LA01HU)
驗證數(shù)據(jù)
IHC image of CSB-PA882173LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
VPS18 Antibodies
VPS18 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025895GA01HU | VPS18 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA882173LA01HU | VPS18 Antibody | Human | ELISA, IHC |
| CSB-PA882173LB01HU | VPS18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA882173LC01HU | VPS18 Antibody, FITC conjugated | Human | |
| CSB-PA882173LD01HU | VPS18 Antibody, Biotin conjugated | Human | ELISA |
VPS18 Proteins
VPS18 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP882173HU CSB-EP882173HU CSB-BP882173HU CSB-MP882173HU CSB-EP882173HU-B |
Recombinant Human Vacuolar protein sorting-associated protein 18 homolog (VPS18), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
