UBE2F
UBE2F，全稱(chēng)為泛素結(jié)合酶E2 F (putative)，是一種參與泛素化過(guò)程的酶。泛素化是指泛素分子與靶蛋白結(jié)合的過(guò)程，這一過(guò)程通常會(huì)導(dǎo)致靶蛋白被蛋白酶體降解，從而調(diào)節(jié)蛋白質(zhì)的穩(wěn)定性。UBE2F蛋白的異常表達(dá)或活性變化與多種癌癥的發(fā)生發(fā)展密切相關(guān)，如肺癌、乳腺癌等。此外，UBE2F蛋白在神經(jīng)退行性疾病中也可能參與異常蛋白聚集的清除障礙。
針對(duì)UBE2F蛋白的藥物研發(fā)主要集中在抑制其泛素化活性或阻斷其與底物蛋白的結(jié)合。例如，MLN4924是一種NAE抑制劑，可以通過(guò)共價(jià)結(jié)合NEDD8，阻斷NAE催化活性，從而抑制所有Cullin蛋白的擬素化修飾，進(jìn)而影響腫瘤細(xì)胞的增殖和凋亡。此外，也有研究者探索通過(guò)激活特定CRL的活性或促進(jìn)特定CRL與特定底物蛋白的結(jié)合，來(lái)誘導(dǎo)促癌蛋白的降解，從而實(shí)現(xiàn)抗腫瘤治療。
熱銷(xiāo)產(chǎn)品
Recombinant Human NEDD8-conjugating enzyme UBE2F (UBE2F) (CSB-EP850248HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
UBE2F Antibody (CSB-PA850248ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850248ESR1HU at dilution of 1:100
UBE2F Antibodies
UBE2F for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA025452GA01HU | UBE2F Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA850248ESR1HU | UBE2F Antibody | Human | ELISA, IHC |
UBE2F Proteins
UBE2F Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP633524BO CSB-EP633524BO CSB-BP633524BO CSB-MP633524BO CSB-EP633524BO-B |
Recombinant Bovine NEDD8-conjugating enzyme UBE2F (UBE2F) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP705800XBF CSB-EP705800XBF CSB-BP705800XBF CSB-MP705800XBF CSB-EP705800XBF-B |
Recombinant Xenopus tropicalis NEDD8-conjugating enzyme UBE2F (ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP726525CH CSB-EP726525CH CSB-BP726525CH CSB-MP726525CH CSB-EP726525CH-B |
Recombinant Chicken NEDD8-conjugating enzyme UBE2F (UBE2F) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP729235RA CSB-EP729235RA CSB-BP729235RA CSB-MP729235RA CSB-EP729235RA-B |
Recombinant Rat NEDD8-conjugating enzyme UBE2F (Ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP746935XBE CSB-EP746935XBE CSB-BP746935XBE CSB-MP746935XBE CSB-EP746935XBE-B |
Recombinant Xenopus laevis NEDD8-conjugating enzyme UBE2F (ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP764689DIL CSB-EP764689DIL CSB-BP764689DIL CSB-MP764689DIL CSB-EP764689DIL-B |
Recombinant Danio rerio NEDD8-conjugating enzyme UBE2F (ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBE2F Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP850248HU CSB-BP850248HU CSB-MP850248HU CSB-EP850248HU-B |
Recombinant Human NEDD8-conjugating enzyme UBE2F (UBE2F) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP850248HU | Recombinant Human NEDD8-conjugating enzyme UBE2F (UBE2F) | E.coli |
UBE2F Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP883941MO CSB-EP883941MO CSB-BP883941MO CSB-MP883941MO CSB-EP883941MO-B |
Recombinant Mouse NEDD8-conjugating enzyme UBE2F (Ube2f) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
