Trpv4
TRPV4，全稱為瞬時受體電位香草酸亞型4，常見別名包括VR-OAC、OTRPC4等。它是一種廣泛分布于人體細(xì)胞表面的通道蛋白，能感知溫和熱刺激、細(xì)胞外滲透壓變化等多種外界信號，參與調(diào)節(jié)血管舒張、軟骨代謝、神經(jīng)信號傳遞等生理活動。
在疾病層面，TRPV4功能異常與多種病癥相關(guān)：骨關(guān)節(jié)炎患者關(guān)節(jié)軟骨中該蛋白活性升高，可能加速軟骨退化；神經(jīng)病理性疼痛時它過度激活，會放大疼痛信號；此外還與多囊腎病、肺部纖維化等疾病的發(fā)展有關(guān)。目前針對TRPV4的藥物研發(fā)聚焦于拮抗劑領(lǐng)域，部分小分子藥物已進(jìn)入臨床試驗(yàn)階段，嘗試用于慢性疼痛、肺部疾病等治療，但尚未獲批上市，仍需驗(yàn)證安全性與療效。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TRPV4 Antibody (CSB-PA881015ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA881015ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA881015ESR1HU at dilution of 1:100
驗(yàn)證數(shù)據(jù)
貨號：CSB-E14199h
規(guī)格：96T/48T
靈敏度：3.9 pg/mL
檢測范圍：15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Trpv4 Antibodies
Trpv4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025096GA01HU | TRPV4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA881015ESR1HU | TRPV4 Antibody | Human | ELISA, IHC |
| CSB-PA004651 | TRPV4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA024643 | TRPV4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA558953 | TRPV4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA160091 | TRPV4 Antibody | Human,Mouse,Rat | WB,ELISA |
Trpv4 Proteins
Trpv4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP863666RA CSB-EP863666RA CSB-BP863666RA CSB-MP863666RA CSB-EP863666RA-B |
Recombinant Rat Transient receptor potential cation channel subfamily V member 4 (Trpv4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Trpv4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP875332MO CSB-EP875332MO CSB-BP875332MO CSB-MP875332MO CSB-EP875332MO-B |
Recombinant Mouse Transient receptor potential cation channel subfamily V member 4 (Trpv4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Trpv4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP881015HU CSB-BP881015HU CSB-MP881015HU CSB-EP881015HU-B |
Recombinant Human Transient receptor potential cation channel subfamily V member 4 (TRPV4), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP881015HU | Recombinant Human Transient receptor potential cation channel subfamily V member 4 (TRPV4), partial | E.coli |
Trpv4 ELISA Kit
Trpv4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14199h | Human transient receptor potential cation channel subfamily V member 4 (TrpV4)ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
