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TNFRSF10B

TNFRSF10B,即腫瘤壞死因子受體超家族成員10B,也稱為死亡受體5(DR5)。它是一種主要在多種組織中表達(dá)的細(xì)胞表面受體,尤其在腫瘤細(xì)胞中表達(dá)水平較高。TNFRSF10B的作用機(jī)制是通過與腫瘤壞死因子相關(guān)的凋亡誘導(dǎo)配體(TRAIL)結(jié)合,觸發(fā)細(xì)胞凋亡信號(hào)通路。其信號(hào)通路涉及TRAIL與TNFRSF10B結(jié)合后,死亡結(jié)構(gòu)域(DD)的聚集,進(jìn)而招募Fas相關(guān)死亡結(jié)構(gòu)域蛋白(FADD)和啟動(dòng)caspase級(jí)聯(lián)反應(yīng),特別是激活caspase-8,導(dǎo)致細(xì)胞程序性死亡。TNFRSF10B在調(diào)控細(xì)胞生存與死亡平衡中扮演關(guān)鍵角色,其在腫瘤細(xì)胞凋亡中的特異性作用使其成為癌癥治療的有希望的靶點(diǎn),有助于開發(fā)新的靶向治療策略,以增強(qiáng)腫瘤細(xì)胞對(duì)凋亡的敏感性。

熱銷產(chǎn)品

Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) (CSB-MP023965HU1d9)

驗(yàn)證數(shù)據(jù)

CSB-MP023965HU1d9

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP023965HU1d9

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF10 (CSB-EP023985HU1a0) at 4 μg/ml can bind Human TNFRSF10B. The EC50 is 3.897-5.215 ng/mL.

Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) (CSB-MP023965HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP023965HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP023965HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFRSF10B at 2 μg/ml can bind Anti-TNFRSF10B recombinant antibody (CSB-RA023965MA2HU). The EC50 is 1.880-2.195 ng/mL.

TNFRSF10B Antibody (CSB-PA08165A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA08165A0Rb

Immunofluorescence staining of HepG2 cells with CSB-PA08165A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TNFRSF10B Antibodies

TNFRSF10B for Homo sapiens (Human)

TNFRSF10B Proteins

TNFRSF10B Proteins for Homo sapiens (Human)

TNFRSF10B Proteins for Mus musculus (Mouse)

TNFRSF10B ELISA Kit

TNFRSF10B ELISA Kit for Homo sapiens (Human)



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