SLC19A1

SLC19A1，即溶質(zhì)載體家族19成員1，別名RFC1。這是一種在人類細(xì)胞中表達(dá)的轉(zhuǎn)運蛋白，主要負(fù)責(zé)將葉酸和其他相關(guān)分子如環(huán)二核苷酸（CDNs）跨膜轉(zhuǎn)運到細(xì)胞內(nèi)。SLC19A1的作用機制涉及與葉酸和抗葉酸藥物的主動轉(zhuǎn)運，通過這種方式，它在維持細(xì)胞內(nèi)葉酸水平和調(diào)節(jié)免疫反應(yīng)中發(fā)揮關(guān)鍵作用。此外，SLC19A1還參與了DNA感應(yīng)途徑，通過轉(zhuǎn)運2'3'-cGAMP激活STING通路，進(jìn)而誘發(fā)免疫反應(yīng)。SLC19A1的功能異常與多種疾病相關(guān)，包括神經(jīng)管缺陷、巨幼紅細(xì)胞性貧血、某些癌癥和自身免疫疾病，是藥物開發(fā)和疾病治療的潛在靶點。

熱銷產(chǎn)品

Recombinant Human Reduced folate transporter (SLC19A1), partial (CSB-EP021429HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLC19A1 Protein

SLC19A1 Proteins

SLC19A1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP021429HU CSB-BP021429HU CSB-MP021429HU CSB-EP021429HU-B	Recombinant Human Reduced folate transporter (SLC19A1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP021429HU	Recombinant Human Reduced folate transporter (SLC19A1), partial	E.coli