SCN2A
SCN2A，全稱為Sodium channel protein type 2 subunit alpha，常見別名包括Nav1.2、HBSCII等。該蛋白屬于電壓門控性鈉通道α亞基2，主要在腦內(nèi)表達(dá)，可與鈉離子通道β亞基組成電壓門控性鈉通道，參與神經(jīng)元電信號(hào)的傳遞。SCN2A蛋白與癲癇、自閉癥等神經(jīng)發(fā)育障礙密切相關(guān)，其突變可導(dǎo)致神經(jīng)元過度興奮或功能喪失，從而引發(fā)癲癇發(fā)作或自閉癥癥狀。目前，針對(duì)SCN2A相關(guān)疾病的治療尚無特效藥物，但已有研究利用患者來源的人腦類器官模型進(jìn)行藥物篩選，發(fā)現(xiàn)卡馬西平等抗癲癇藥對(duì)SCN2A突變體的效果各異，為精準(zhǔn)治療提供了新的思路。此外，個(gè)性化反義寡核苷酸療法也在探索中，旨在通過降低SCN2A突變體的表達(dá)來改善患者癥狀。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA937791(SCN2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA937791(SCN2A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
SCN2A Antibodies
SCN2A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA040291 | SCN2A Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA040292 | SCN2A Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA937791 | SCN2A Antibody | Human,Rat | ELISA,IHC |
| CSB-PA902560 | SCN2A Antibody | Human,Rat | ELISA,IHC |
SCN2A Proteins
SCN2A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP857853HU CSB-EP857853HU CSB-BP857853HU CSB-MP857853HU CSB-EP857853HU-B |
Recombinant Human Sodium channel protein type 2 subunit alpha (SCN2A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
