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RAD21

Double-strand-break repair protein rad21 homolog is a protein in humans that is encoded by RAD21 gene. Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis.

RAD21 Antibodies

RAD21 for Homo sapiens (Human)

RAD21 Proteins

RAD21 Proteins for Homo sapiens (Human)

RAD21 Proteins for Xenopus laevis (African clawed frog)

RAD21 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

RAD21 Proteins for Bos taurus (Bovine)

RAD21 Proteins for Mus musculus (Mouse)



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