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RAB27A

RAB27A,全稱(chēng)為Ras相關(guān)蛋白R(shí)ab-27A,常用別名有Rab27、MSP等。它是細(xì)胞內(nèi)囊泡運(yùn)輸?shù)年P(guān)鍵參與者,能調(diào)控囊泡與靶膜的錨定或融合,介導(dǎo)黑色素小體分泌、免疫細(xì)胞顆粒釋放等生理過(guò)程——比如黑色素細(xì)胞中,它幫助黑色素小體到達(dá)細(xì)胞膜并釋放色素,若這一過(guò)程異常會(huì)影響皮膚毛發(fā)的顏色。
RAB27A突變時(shí),可能引發(fā)格里塞利綜合征2型,患者常出現(xiàn)皮膚毛發(fā)色素變淺、免疫功能低下,部分還伴有神經(jīng)系統(tǒng)損傷。在乳腺癌、肺癌等腫瘤中,該蛋白表達(dá)常異常升高,通過(guò)促進(jìn)腫瘤外泌體釋放增強(qiáng)癌細(xì)胞侵襲轉(zhuǎn)移能力。目前針對(duì)其在腫瘤中的作用,科研人員正探索靶向抑制的小分子化合物,部分候選藥物處于早期實(shí)驗(yàn)室研究階段,有望為相關(guān)疾病治療提供新方向。

熱銷(xiāo)產(chǎn)品

Recombinant Human Ras-related protein Rab-27A (RAB27A) (CSB-YP019177HU)

驗(yàn)證數(shù)據(jù)

CSB-YP019177HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RAB27A Recombinant Monoclonal Antibody (CSB-RA285197A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA285197A0HU

Overlay Peak curve showing PC3 cells stained with CSB-RA285197A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

RAB27A Antibody (CSB-PA019177LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA019177LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA019177LA01HU at dilution of 1:100

CSB-PA019177LA01HU

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA019177LA01HU at dilution of 1:100

CSB-PA019177LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA019177LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

RAB27A Antibodies

RAB27A for Homo sapiens (Human)

RAB27A Proteins

RAB27A Proteins for Homo sapiens (Human)



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