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PRKG2

cGMP-dependent protein kinase 2 is a protein in humans that is encoded by PRKG2 gene. Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).

PRKG2 Antibodies

PRKG2 for Homo sapiens (Human)

PRKG2 Proteins

PRKG2 Proteins for Homo sapiens (Human)

PRKG2 Proteins for Rattus norvegicus (Rat)

PRKG2 Proteins for Mus musculus (Mouse)



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