POSTN
POSTN，全稱為Periostin，別名OSF2、PDLPOSTN、PN，是一種細(xì)胞外基質(zhì)分泌蛋白，在心肌梗死后的組織發(fā)育和再生中發(fā)揮重要作用，涉及傷口愈合和心室重構(gòu)。該蛋白與整合素和BMP1結(jié)合，支持細(xì)胞粘附、細(xì)胞遷移，與多種生理和病理過程相關(guān)。POSTN在骨關(guān)節(jié)炎的軟骨細(xì)胞中高度表達(dá)，促進(jìn)細(xì)胞外基質(zhì)的降解和上調(diào)炎癥因子，加速疾病進(jìn)展。此外，POSTN還與腫瘤的遷移、增殖和血管生成能力有關(guān)，在多種腫瘤組織中表達(dá)上調(diào)。在藥物研發(fā)方面，針對(duì)POSTN的藥物正在開發(fā)中，旨在通過抑制POSTN的表達(dá)或活性，治療心血管疾病、骨關(guān)節(jié)炎和腫瘤等疾病。一些研究顯示，抑制POSTN可以減少心臟瓣膜疾病、骨骼和牙齒缺陷的發(fā)生。目前，POSTN已成為藥物研發(fā)的一個(gè)重要靶點(diǎn)，相關(guān)藥物正處于臨床研究階段。
熱銷產(chǎn)品
POSTN Recombinant Monoclonal Antibody (CSB-RA119753A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U251 whole cell lysate(30μg), JK whole cell lysate(30μg), 293 whole cell lysate(30μg), MCF7 whole cell lysate(30μg)
All lanes: POSTN antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 94,88,84,91,81,87 kDa
Observed band size: 100 kDa
Exposure time: 120s
Overlay Peak curve showing HEK293T cells surface stained with CSB-RA119753A0HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃. Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed
Human periostin/osteoblast specific factor 2 (POSTN) ELISA kit (CSB-E16444h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E16444h
規(guī)格：96T/48T
靈敏度：1.56 ng/mL
檢測(cè)范圍：6.25 ng/mL-400 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
POSTN Antibodies
POSTN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA09905C0Rb | POSTN Antibody, FITC conjugated | Human | |
| CSB-PA09905A0Rb | POSTN Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA018381GA01HU | POSTN Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA619962ESR2HU | POSTN Antibody | Human | ELISA, IHC |
| CSB-RA119753A0HU | POSTN Recombinant Monoclonal Antibody | Human | ELISA, WB, FC |
| CSB-RA619962MA1HU | POSTN Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
POSTN ELISA Kit
POSTN ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16444h | Human periostin/osteoblast specific factor 2 (POSTN) ELISA kit | serum, plasma, tissue homogenates | 1.56 ng/mL |
