1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 is a protein in humans that is encoded by PLCG2 gene. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.