PKMYT1
PKMYT1，蛋白全稱為膜相關(guān)酪氨酸/蘇氨酸蛋白激酶1，常見別名包括MYT1。這種蛋白是一種定位于細(xì)胞膜的激酶分子，核心作用是參與細(xì)胞分裂進(jìn)程的精準(zhǔn)調(diào)控——它通過對(duì)細(xì)胞周期關(guān)鍵蛋白的修飾，延緩細(xì)胞從DNA復(fù)制后期進(jìn)入分裂階段，確保細(xì)胞在遺傳物質(zhì)完全復(fù)制且無誤后再啟動(dòng)分裂，維持細(xì)胞增殖的正常秩序。
PKMYT1活性異常時(shí)，細(xì)胞分裂的調(diào)控機(jī)制易失衡，進(jìn)而推動(dòng)腫瘤發(fā)生發(fā)展。比如在肺癌、乳腺癌等惡性腫瘤中，常能檢測到它的表達(dá)水平顯著升高，這會(huì)加速腫瘤細(xì)胞的無序增殖與擴(kuò)散。目前針對(duì)它的靶向干預(yù)研究正逐步推進(jìn)，部分小分子抑制劑已在臨床前實(shí)驗(yàn)中展現(xiàn)潛力：這些化合物可特異性阻斷其功能，幫助恢復(fù)細(xì)胞周期節(jié)律，對(duì)腫瘤細(xì)胞產(chǎn)生抑制效果，為相關(guān)癌癥治療提供了新的潛在方向。
熱銷產(chǎn)品
PKMYT1 Antibody (CSB-PA16029A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA16029A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16029A0Rb at dilution of 1:100
PKMYT1 Antibodies
PKMYT1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA16029A0Rb | PKMYT1 Antibody | Human | ELISA, IHC |
| CSB-PA018073GA01HU | PKMYT1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA729561 | Phospho-PKMYT1 (Ser83) Antibody | Human | ELISA,IHC |
| CSB-PA003356 | PKMYT1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA070226 | Phospho-PKMYT1 (S83) Antibody | Human | IHC, ELISA |
| CSB-PA254680 | PKMYT1 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA955430 | PKMYT1 Antibody | Human,Mouse | ELISA,WB,IHC |
PKMYT1 Proteins
PKMYT1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP849597XBE CSB-EP849597XBE CSB-BP849597XBE CSB-MP849597XBE CSB-EP849597XBE-B |
Recombinant Xenopus laevis Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (pkmyt1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PKMYT1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858720HU CSB-EP858720HU CSB-BP858720HU CSB-MP858720HU CSB-EP858720HU-B |
Recombinant Human Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PKMYT1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP866844MO CSB-EP866844MO CSB-BP866844MO CSB-MP866844MO CSB-EP866844MO-B |
Recombinant Mouse Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Pkmyt1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
