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NTRK2

NTRK2全稱為神經(jīng)營養(yǎng)酪氨酸激酶受體2型(Neurotrophic Tyrosine Kinase Receptor Type 2),常簡稱為TrkB或GP145-TrkB。NTRK2是腦源性神經(jīng)營養(yǎng)因子(BDNF)的主要受體,通過與配體結(jié)合激活下游信號網(wǎng)絡(luò),調(diào)控神經(jīng)元存活、突觸可塑性和神經(jīng)遞質(zhì)釋放,對學習記憶、情緒調(diào)節(jié)等腦功能至關(guān)重要。NTRK2信號異常與阿爾茨海默病、抑郁癥、癲癇等神經(jīng)系統(tǒng)疾病密切相關(guān),其過度激活也可能導致神經(jīng)母細胞瘤、肺癌等實體瘤的發(fā)生。近年來針對NTRK基因家族融合突變的靶向治療取得突破,拉羅替尼(Larotrectinib)和恩曲替尼(Entrectinib)等泛TRK抑制劑已獲批用于NTRK融合陽性的實體瘤患者,但部分患者用藥后出現(xiàn)的激酶區(qū)耐藥突變?nèi)允桥R床挑戰(zhàn)。目前第二代TRK抑制劑如Selitrectinib正在研發(fā)中,旨在克服獲得性耐藥問題。

熱銷產(chǎn)品

NTRK2 Recombinant Monoclonal Antibody (CSB-RA619082MA1HU)

驗證數(shù)據(jù)

CSB-RA619082MA1HU

Immunofluorescence staining of SH-SY5Y cell with CSB-RA619082MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

NTRK2 Antibodies

NTRK2 for Homo sapiens (Human)

NTRK2 Proteins

NTRK2 Proteins for Mus musculus (Mouse)

NTRK2 Proteins for Homo sapiens (Human)

NTRK2 Proteins for Rattus norvegicus (Rat)

NTRK2 Proteins for Gallus gallus (Chicken)



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