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NRAS

NRAS,即神經母細胞瘤RAS病毒癌基因同源物。別名N-ras、NRAS1。NRAS基因編碼一種GTP結合蛋白,在細胞信號傳導中起著分子開關的作用。它通過與GTP或GDP結合來循環激活和失活狀態,控制細胞生長、分化和凋亡。NRAS的作用機制涉及RAS/RAF/MEK/ERK信號通路的激活,該通路控制基因轉錄活動和細胞周期,與細胞增殖相關。NRAS基因突變可導致蛋白持續激活,從而促進腫瘤的發生和發展,如黑色素瘤、結直腸癌、非小細胞肺癌等。

熱銷產品

Recombinant Human GTPase NRas (NRAS) (CSB-EP016070HU)

驗證數據

CSB-EP016070HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NRAS Antibody (CSB-PA016070LA01HU)

驗證數據

CSB-PA016070LA01HU

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA016070LA01HU at dilution of 1:100

CSB-PA016070LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA016070LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

NRAS Antibodies

NRAS for Homo sapiens (Human)

NRAS Proteins

NRAS Proteins for Cavia porcellus (Guinea pig)

NRAS Proteins for Mus musculus (Mouse)

NRAS Proteins for Homo sapiens (Human)

NRAS Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NRAS Proteins for Sus scrofa (Pig)

NRAS Proteins for Gallus gallus (Chicken)

NRAS Proteins for Pongo abelii (Sumatran orangutan)

NRAS Proteins for Xenopus laevis (African clawed frog)

NRAS Proteins for Monodelphis domestica (Gray short-tailed opossum)



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