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NEDD4L

E3 ubiquitin-protein ligase NEDD4-like is a protein in humans that is encoded by NEDD4L gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5.

NEDD4L Antibodies

NEDD4L for Homo sapiens (Human)

NEDD4L Proteins

NEDD4L Proteins for Pongo abelii (Sumatran orangutan)

NEDD4L Proteins for Mus musculus (Mouse)

NEDD4L Proteins for Homo sapiens (Human)



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