NECTIN2
NECTIN2，全稱為Nectin-2，也被稱為CD112、HVEB、PVRL2，是一種參與細胞連接和信號傳導(dǎo)的重要蛋白。它作為細胞粘附分子，在細胞間相互作用中發(fā)揮關(guān)鍵作用，并與某些病毒（如單純皰疹病毒）的感染相關(guān)。NECTIN2蛋白在免疫細胞和其他類型細胞間的相互作用中影響細胞遷移和組織穩(wěn)態(tài)，同時也在癌癥和病毒感染等多種疾病中發(fā)揮作用。目前，針對NECTIN2的藥物研發(fā)主要集中在癌癥治療領(lǐng)域，已有多個靶向NECTIN2的藥物處于研發(fā)階段。例如，橙帆醫(yī)藥與Avenzo Therapeutics達成了全球戰(zhàn)略合作協(xié)議，共同研發(fā)和商業(yè)化一種Nectin4-TROP2雙抗ADC藥物，旨在治療晚期實體瘤。此外，NECTIN2蛋白還與乳腺癌和卵巢癌等疾病相關(guān)，使其成為抗體治療的潛在靶點。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis NECTIN2 at 2 μg/ml can bind Anti-NECTIN2 recombinant antibody(CSB-RA835690MA1HU). The EC50 is 1.011-1.193 ng/mL.
The purity of NECTIN2 was greater than 95% as determined by SEC-HPLC
Recombinant Human Nectin-2 (NECTIN2), partial (CSB-MP835690HUd7)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NECTIN2 Antibody (CSB-PA835690LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
All lanes: NECTIN2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58, 52 kDa
Observed band size: 58 kDa
NECTIN2 Antibodies
NECTIN2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019096GA01HU | PVRL2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006259 | PVRL2 Antibody | Human | WB, ELISA |
| CSB-PA163325 | PVRL2 Antibody | Human | ELISA,IHC |
| CSB-PA835690LA01HU | NECTIN2 Antibody | Human | ELISA, WB |
| CSB-PA835690LB01HU | NECTIN2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA835690LC01HU | NECTIN2 Antibody, FITC conjugated | Human |
NECTIN2 Proteins
NECTIN2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019096MO1 CSB-EP019096MO1 CSB-BP019096MO1 CSB-MP019096MO1 CSB-EP019096MO1-B |
Recombinant Mouse Poliovirus receptor-related protein 2 (Pvrl2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF019096MO | Recombinant Mouse Nectin-2 (Nectin2) | in vitro E.coli expression system |
NECTIN2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP835690HU CSB-BP835690HU CSB-MP835690HU CSB-EP835690HU-B |
Recombinant Human Poliovirus receptor-related protein 2 (PVRL2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP835690HU | Recombinant Human Nectin-2 (PVRL2), partial | E.coli |
| CSB-AP005081HU | Recombinant Human Nectin-2 (NECTIN2), partial (Active) | Mammalian cell |
