NAMPT

NAMPT，即煙酰胺磷酸核糖基轉(zhuǎn)移酶，別名PBEF、Visfatin、前B細(xì)胞集落增強(qiáng)因子等。它是一種由NAMPT基因編碼的多功能蛋白，主要在多種組織中表達(dá)，如棕色脂肪組織、肝臟、腎臟等，尤其在脂肪組織中表達(dá)量較高。NAMPT的作用機(jī)制主要是催化煙酰胺(NAM)和5'-磷酸核糖焦磷酸(PRPP)合成煙酰胺單核苷酸(NMN)，這是NAD+合成補(bǔ)救途徑的第一步和限速步驟。NAMPT在生物學(xué)上的意義非常廣泛，它不僅在細(xì)胞內(nèi)NAD+的合成和能量代謝中發(fā)揮關(guān)鍵作用，還以分泌型eNAMPT的形式參與多種生理和病理過(guò)程的調(diào)節(jié)。eNAMPT具有細(xì)胞因子樣活性，能夠促進(jìn)炎癥和血管生成，與腫瘤的發(fā)生、發(fā)展以及轉(zhuǎn)移密切相關(guān)。此外，NAMPT的表達(dá)水平在代謝性疾病、神經(jīng)退行性疾病、衰老和癌癥等多種年齡相關(guān)性疾病中發(fā)生變化，提示其在這些疾病中可能發(fā)揮重要作用。因此，NAMPT是藥物開(kāi)發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)，針對(duì)NAMPT的激活劑和抑制劑正在被研究用于治療相關(guān)疾病。

熱銷產(chǎn)品

Recombinant Mouse Nicotinamide phosphoribosyltransferase (Nampt) (CSB-YP015422MOb0)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NAMPT Antibody (CSB-PA015422ESR2HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: Nicotinamide phosphoribosyltransferase antibody at 4μg/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse liver tissue
Lane 3: Mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA015422ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015422ESR2HU at dilution of 1:100

NAMPT Antibody

NAMPT Protein

NAMPT ELISA Kit

NAMPT Antibodies

NAMPT for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA015422GA01HU	NAMPT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA015422ESR1HU	NAMPT Antibody	Human	ELISA, IHC, IP
CSB-PA015422ESR2HU	NAMPT Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA215740	NAMPT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA200625	NAMPT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA015422EA01HU	NAMPT Antibody	Human	ELISA, WB, IHC, IF
CSB-PA015422EB01HU	NAMPT Antibody, HRP conjugated	Human	ELISA
CSB-PA015422EC01HU	NAMPT Antibody, FITC conjugated	Human
CSB-PA015422ED01HU	NAMPT Antibody, Biotin conjugated	Human	ELISA

NAMPT for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA015422LA01RA	Nampt Antibody	Rat, Human	ELISA, WB
CSB-PA015422LB01RA	Nampt Antibody, HRP conjugated	Rat	ELISA
CSB-PA015422LC01RA	Nampt Antibody, FITC conjugated	Rat
CSB-PA015422LD01RA	Nampt Antibody, Biotin conjugated	Rat	ELISA

NAMPT Proteins

NAMPT Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP015422HU CSB-EP015422HU CSB-BP015422HU CSB-MP015422HU CSB-EP015422HU-B	Recombinant Human Nicotinamide phosphoribosyltransferase (NAMPT)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NAMPT Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP015422PI CSB-EP015422PI CSB-BP015422PI CSB-MP015422PI CSB-EP015422PI-B	Recombinant Pig Nicotinamide phosphoribosyltransferase (NAMPT)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NAMPT Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP015422RA CSB-EP015422RA CSB-BP015422RA CSB-MP015422RA CSB-EP015422RA-B	Recombinant Rat Nicotinamide phosphoribosyltransferase (Nampt)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NAMPT Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP015422MO CSB-BP015422MO CSB-EP015422MO-B	Recombinant Mouse Nicotinamide phosphoribosyltransferase (Nampt)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP015422MO(M1)	Recombinant Mouse Nicotinamide phosphoribosyltransferase (Nampt) (C39S)	E.coli
CSB-EP015422MO	Recombinant Mouse Nicotinamide phosphoribosyltransferase (Nampt)	E.coli
CSB-EP015422MOe1	Recombinant Mouse Nicotinamide phosphoribosyltransferase (Nampt)	E.coli
CSB-YP015422MOb0	Recombinant Mouse Nicotinamide phosphoribosyltransferase (Nampt)	Yeast