MMP13

MMP13，全稱為基質金屬蛋白酶13，常用別名是膠原酶3。它的核心功能是分解體內的膠原蛋白——這種蛋白是軟骨、骨骼等組織的關鍵結構成分。正常情況下，它參與傷口愈合、骨骼發育等生理過程，維持組織的動態平衡；但活性異常升高時，會打破這種平衡帶來健康問題。
比如骨關節炎患者的關節軟骨中，MMP13會過度分解膠原蛋白，導致軟骨變薄磨損，引發關節疼痛僵硬；部分癌癥里，它也能幫助腫瘤細胞突破周圍組織束縛，促進轉移擴散。針對它的藥物研發主要是抑制活性：早期抑制劑因特異性不足，易影響其他正常酶功能，副作用明顯；現在更傾向于開發精準靶向的制劑，希望控制其活性治療骨關節炎或相關癌癥。

熱銷產品

Recombinant Human Collagenase 3 (MMP13), partial (CSB-EP014660HU3)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MMP13 Antibody (CSB-PA07029A0Rb)

驗證數據

Western Blot
Positive WB detected in: PC-3 whole cell lysate, Mouse kidney tissue, Mouse lung tissue
All lanes: MMP13 antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA07029A0Rb at dilution of 1:100

Immunofluorescent analysis of PC-3 cells using CSB-PA07029A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Matrix metalloproteinase 13,MMP-13 ELISA kit (CSB-E04674h)

驗證數據

貨號：CSB-E04674h

規格：96T/48T

靈敏度：0.039 ng/mL

檢測范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MMP13 Antibody

MMP13 Protein

MMP13 ELISA Kit

MMP13 Antibodies

MMP13 for Mus musculus (Mouse)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA17739C0Rb	Mmp13 Antibody, FITC conjugated	Mouse
CSB-PA17739A0Rb	Mmp13 Antibody	Mouse	ELISA, IHC
CSB-PA17739D0Rb	Mmp13 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA17739B0Rb	Mmp13 Antibody, HRP conjugated	Mouse	ELISA

MMP13 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA07029A0Rb	MMP13 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA07029B0Rb	MMP13 Antibody, HRP conjugated	Human	ELISA
CSB-PA07029C0Rb	MMP13 Antibody, FITC conjugated	Human
CSB-PA07029D0Rb	MMP13 Antibody, Biotin conjugated	Human	ELISA
CSB-PA014660GA01HU	MMP13 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA981877	MMP13 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA003255	MMP13 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA797584	MMP13 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

MMP13 Proteins

MMP13 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP014660MO CSB-BP014660MO CSB-MP014660MO CSB-EP014660MO-B	Recombinant Mouse Collagenase 3 (Mmp13)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP014660MO	Recombinant Mouse Collagenase 3 (Mmp13)	E.coli

MMP13 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP014660HU CSB-BP014660HU CSB-MP014660HU CSB-EP014660HU-B	Recombinant Human Collagenase 3 (MMP13)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP014660HU	Recombinant Human Collagenase 3 (MMP13)	E.coli
CSB-EP014660HU3	Recombinant Human Collagenase 3 (MMP13), partial	E.coli

MMP13 Proteins for Equus caballus (Horse)

產品貨號	產品名稱	來源
CSB-YP014660HO CSB-EP014660HO CSB-BP014660HO CSB-MP014660HO CSB-EP014660HO-B	Recombinant Horse Collagenase 3 (MMP13)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MMP13 Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP014660RB CSB-EP014660RB CSB-BP014660RB CSB-MP014660RB CSB-EP014660RB-B	Recombinant Rabbit Collagenase 3 (MMP13)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MMP13 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP014660BO CSB-EP014660BO CSB-BP014660BO CSB-MP014660BO CSB-EP014660BO-B	Recombinant Bovine Collagenase 3 (MMP13)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MMP13 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP014660RA CSB-BP014660RA CSB-MP014660RA CSB-EP014660RA-B	Recombinant Rat Collagenase 3 (Mmp13)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MMP13 Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP607442XBE CSB-EP607442XBE CSB-BP607442XBE CSB-MP607442XBE CSB-EP607442XBE-B	Recombinant Xenopus laevis Collagenase 3 (mmp13)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli