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MAPK8IP1

C-Jun-amino-terminal kinase-interacting protein 1 is a protein in humans that is encoded by MAPK8IP1 gene. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

MAPK8IP1 Antibodies

MAPK8IP1 for Homo sapiens (Human)

MAPK8IP1 Proteins

MAPK8IP1 Proteins for Rattus norvegicus (Rat)

MAPK8IP1 Proteins for Homo sapiens (Human)

MAPK8IP1 Proteins for Mus musculus (Mouse)



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