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IL2RA

白介素-2受體α亞基(IL2RA)也被稱為Tac抗原、P55、CD25,是一種細胞表面蛋白,與β亞基(CD122)、γ亞基(CD132)共同組成白介素-2受體。該蛋白主要參與免疫細胞的信號傳遞,尤其在維持免疫耐受和調節性T細胞功能中起核心作用。IL2RA在免疫系統中發揮重要作用,與T細胞的增殖、存活和分化密切相關。IL2RA蛋白的表達和功能異常與類風濕性關節炎、1型糖尿病等疾病的發生發展密切相關。首個基于IL-2的藥物(aldesleukin:重組IL-2)于1992年被FDA批準,用于治療轉移性腎癌;1998年,該藥又被批準用于治療轉移性黑色素瘤。目前,IL2RA作為免疫調節研究領域的熱點,相關藥物研發仍在持續進行中。

熱銷產品

Recombinant Macaca fascicularis Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) (CSB-MP5104MOV)

驗證數據

CSB-MP5104MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5104MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL2RA at 2 μg/ml can bind Macaca fascicularis IL2 (CSB-MP640916MOVd9). The EC50 is 88.60-116.8 ng/mL.

CSB-MP5104MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL2RA at 2 μg/ml can bind Human IL2 (CSB-MP011629HU). The EC50 is 0.8151-1.087 ng/mL.

CSB-MP5104MOV

Activity
Macaca fascicularis IL2 (CSB-MP640916MOVd9) captured on Protein A Chip can bind Recombinant Macaca fascicularis IL2RA with an affinity constant of 31.3 nM as detected by MetaSPR Assay (WeSPRTM 200).

CSB-MP5104MOV

The purity of IL2RA was greater than 95% as determined by SEC-HPLC

Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) (CSB-MP011649HU3)

驗證數據

CSB-MP011649HU3

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP011649HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP011649HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Human IL2(CSB-MP011629HU),the EC50 is 1.693-2.039 ng/mL.

Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial (Active) (CSB-MP011649MO1)

驗證數據

CSB-MP011649MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP011649MO1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Il2ra at 2 μg/ml can bind Mouse Il2 (CSB-MP011629MOd9). The EC50 is 95.00-116.2 ng/mL.

CSB-MP011649MO1

The purity of Il2ra was greater than 95% as determined by SEC-HPLC

IL2RA Recombinant Monoclonal Antibody (CSB-RA011649MA1HU)

驗證數據

CSB-RA011649MA1HU

The Binding Activity of Human IL2RA with Anti-IL2RA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA (CSB-MP011649HU3) at 2 μg/mL can bind Anti-IL2RA recombinant antibody , the EC50 is 2.463-3.353 ng/mL.

CSB-RA011649MA1HU

Immunofluorescence staining of Hela cell with CSB-RA011649MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

CSB-RA011649MA1HU

Immunofluorescence staining of HEPG2 cell with CSB-RA011649MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

Human soluble interleukin-2 receptor,IL-2sRα ELISA kit (CSB-E04629h)

驗證數據

CSB-E04629h 標準曲線

貨號:CSB-E04629h

規格:96T/48T

靈敏度:19.5 pg/mL

檢測范圍:78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IL2RA Antibodies

IL2RA for H

IL2RA for Homo sapiens (Human)

IL2RA Proteins

IL2RA Proteins for Bos taurus (Bovine)

IL2RA Proteins for Ovis aries (Sheep)

IL2RA Proteins for Felis catus (Cat) (Felis silvestris catus)

IL2RA Proteins for Rattus norvegicus (Rat)

IL2RA Proteins for Homo sapiens (Human)

IL2RA Proteins for Mus musculus (Mouse)

IL2RA Proteins for Sus scrofa (Pig)

IL2RA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

IL2RA Proteins for Pan troglodytes (Chimpanzee)

IL2RA Proteins for Macaca mulatta (Rhesus macaque)

IL2RA ELISA Kit

IL2RA ELISA Kit for Homo sapiens (Human)

IL2RA ELISA Kit for Mus musculus (Mouse)



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