GRM1
GRM1，全名為谷氨酸代謝型受體1（mGluR1），別名包括GPRC1A、MGLU1、MGLUR1等。該蛋白屬于谷氨酸受體家族，通過激活磷脂酶c發(fā)揮作用，參與神經(jīng)遞質(zhì)的傳遞和調(diào)節(jié)。GRM1蛋白與多種疾病相關(guān)，如脊髓小腦性共濟(jì)失調(diào)44（SCA44）和常染色體隱性小腦性共濟(jì)失調(diào)13（SCAR13）。SCA44是由新的de novo GRM1變異c.2303 C＞T（p.Thr768Ile）引起的，該變異通過增加mGluR1的組成性活性導(dǎo)致疾病。而SCAR13則與mGluR1功能喪失相關(guān)。在藥物研發(fā)方面，利魯唑等藥物被用于治療側(cè)索硬化癥，顯示出對mGluR1功能的調(diào)節(jié)作用。目前，針對GRM1蛋白的藥物研發(fā)仍在進(jìn)行中，旨在恢復(fù)其正常功能，為相關(guān)疾病的治療提供新的思路。
熱銷產(chǎn)品
GRM1 Antibody (CSB-PA009931LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA009931LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA009931LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GRM1 Antibodies
GRM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009931GA01HU | GRM1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009017 | GRM1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA054030 | GRM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA559950 | GRM1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA009931LA01HU | GRM1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA009931LB01HU | GRM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009931LC01HU | GRM1 Antibody, FITC conjugated | Human | |
| CSB-PA009931LD01HU | GRM1 Antibody, Biotin conjugated | Human | ELISA |
GRM1 Proteins
GRM1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009931MO CSB-EP009931MO CSB-BP009931MO CSB-MP009931MO CSB-EP009931MO-B |
Recombinant Mouse Metabotropic glutamate receptor 1 (Grm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRM1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009931RA CSB-EP009931RA CSB-BP009931RA CSB-MP009931RA CSB-EP009931RA-B |
Recombinant Rat Metabotropic glutamate receptor 1 (Grm1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP615673HU CSB-EP615673HU CSB-BP615673HU CSB-MP615673HU CSB-EP615673HU-B |
Recombinant Human Metabotropic glutamate receptor 1 (GRM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
