G6PC1
G6PC1，全稱為葡萄糖-6-磷酸酶催化亞基1，是一種位于內(nèi)質(zhì)網(wǎng)的多亞基整合膜蛋白。該蛋白參與葡萄糖代謝的關(guān)鍵過程，負(fù)責(zé)將葡萄糖-6-磷酸（G6P）水解為葡萄糖，從而維持血糖穩(wěn)態(tài)。G6PC1蛋白的常見別名包括G6Pase、GSD1A1等。G6PC1蛋白的功能異常或突變會(huì)導(dǎo)致I型糖原貯積癥（GSD-1a），這是一種罕見的遺傳代謝疾病，患者會(huì)出現(xiàn)嚴(yán)重的低血糖癥狀，同時(shí)伴有肝臟和腎臟中糖原和脂肪的積累。此外，G6PC1蛋白的活性異常也與糖尿病患者的葡萄糖代謝紊亂密切相關(guān)，因此成為治療糖代謝紊亂的重要靶點(diǎn)。目前，針對(duì)G6PC1蛋白的藥物研發(fā)主要集中在開發(fā)能夠調(diào)節(jié)其活性的小分子藥物，以治療GSD-1a和糖尿病等疾病。
熱銷產(chǎn)品
Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial (CSB-EP009118HU1a2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
G6PC1 Antibodies
G6PC1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009118LA01HU | G6PC Antibody | Human | ELISA, IHC |
| CSB-PA009118LB01HU | G6PC Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009118LD01HU | G6PC Antibody, Biotin conjugated | Human | ELISA |
G6PC1 Proteins
G6PC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP009118HU1 CSB-BP009118HU1 CSB-MP009118HU1 CSB-EP009118HU1-B |
Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP009118HU1a2 | Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial | E.coli |
| CSB-YP009118HU1 | Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial | Yeast |
| CSB-YP009118HU1a4 | Recombinant Human Glucose-6-phosphatase catalytic subunit 1 (G6PC1), partial | Yeast |
