FZD10
Frizzled-10（FZD10）是Frizzled家族的跨膜蛋白，作為Wnt配體的受體參與細(xì)胞內(nèi)的信號(hào)傳遞，調(diào)控細(xì)胞生長(zhǎng)、分化和遷移等核心生命過程。正常情況下，它的表達(dá)維持著組織的平衡狀態(tài)，但異常表達(dá)時(shí)可能卷入疾病的發(fā)生發(fā)展。
例如在結(jié)直腸癌、胃癌等多種惡性腫瘤中，F(xiàn)ZD10的水平常明顯升高，它能增強(qiáng)腫瘤細(xì)胞的增殖活性、促進(jìn)血管生成，甚至幫助腫瘤細(xì)胞逃避死亡，從而推動(dòng)腫瘤的生長(zhǎng)和擴(kuò)散。目前針對(duì)FZD10的藥物研發(fā)正在推進(jìn)，一些靶向該蛋白的單克隆抗體已進(jìn)入臨床前實(shí)驗(yàn)階段，希望通過阻斷它與配體的結(jié)合來抑制腫瘤進(jìn)展，為相關(guān)癌癥治療開辟新的可能。此外，F(xiàn)ZD10在胚胎發(fā)育中也有一定作用，其表達(dá)紊亂可能與某些發(fā)育異常有關(guān)，但這方面的研究仍需深入探索。
熱銷產(chǎn)品
FZD10 Antibody (CSB-PA891782LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate
All lanes: FZD10 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66 kDa
Observed band size: 66 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA891782LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA891782LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA891782LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
FZD10 Antibodies
FZD10 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009104GA01HU | FZD10 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005299 | FZD10 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA006791 | FZD10 Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
| CSB-PA970487 | FZD10 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA891782LA01HU | FZD10 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA891782LC01HU | FZD10 Antibody, FITC conjugated | Human | |
| CSB-PA891782LD01HU | FZD10 Antibody, Biotin conjugated | Human | ELISA |
FZD10 Proteins
FZD10 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP803892MO1 CSB-EP803892MO1 CSB-BP803892MO1 CSB-MP803892MO1 CSB-EP803892MO1-B |
Recombinant Mouse Frizzled-10 (Fzd10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF803892MO | Recombinant Mouse Frizzled-10 (Fzd10) | in vitro E.coli expression system |
FZD10 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP886116CH1 CSB-EP886116CH1 CSB-BP886116CH1 CSB-MP886116CH1 CSB-EP886116CH1-B |
Recombinant Chicken Frizzled-10 (FZD10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886116CH | Recombinant Chicken Frizzled-10 (FZD10) | in vitro E.coli expression system |
FZD10 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP891782HU1 CSB-EP891782HU1 CSB-BP891782HU1 CSB-MP891782HU1 CSB-EP891782HU1-B |
Recombinant Human Frizzled-10 (FZD10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF891782HU | Recombinant Human Frizzled-10 (FZD10) | in vitro E.coli expression system |
