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Your Good Partner in Biology Research

FOSL1

FOSL1(FOS-like antigen 1)又稱Fra-1,屬于AP-1轉錄因子家族成員,在細胞增殖、分化和凋亡中發揮調控作用。FOSL1通過與JUN家族蛋白形成二聚體,結合特定DNA序列激活下游靶基因,尤其與腫瘤侵襲轉移密切相關。有研究發現,FOSL1在乳腺癌、結直腸癌和肺癌等多種惡性腫瘤中異常高表達,通過誘導上皮間質轉化(EMT)促進癌細胞遷移,并與血管生成、化療耐藥等惡性表型相關。其活性受MAPK/ERK和JNK等信號通路調控,與炎癥因子TNF-α、IL-6的表達也存在交叉調控。目前針對FOSL1尚無直接靶向藥物,但針對其上游信號分子開發的MEK抑制劑(如曲美替尼)已在臨床試驗中驗證對部分腫瘤的療效。近年研究發現,天然化合物姜黃素可通過抑制FOSL1表達延緩腫瘤進展,為聯合用藥提供了新方向。

熱銷產品

FOSL1 Antibody (CSB-PA008792DSR1HU)

驗證數據

CSB-PA008792DSR1HU

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008792DSR1HU at dilution of 1:100

CSB-PA008792DSR1HU

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA008792DSR1HU at dilution of 1:100

CSB-PA008792DSR1HU

Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA008792DSR1HU at dilution of 1:100

FOSL1 Antibodies

FOSL1 for Homo sapiens (Human)

FOSL1 Proteins

FOSL1 Proteins for Rattus norvegicus (Rat)

FOSL1 Proteins for Homo sapiens (Human)

FOSL1 Proteins for Mus musculus (Mouse)



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