FBXO3
FBXO3，別名FBA、FBX3。FBXO3由人類FBXO3基因編碼，該基因位于染色體11p13位置。FBXO3是F-box蛋白家族的成員，其特征是含有約40個(gè)氨基酸的F-box基序。F-box蛋白是SCF（SKP1-Cullin-F-box）泛素蛋白連接酶復(fù)合體的四個(gè)亞基之一，參與磷酸化依賴性泛素化過(guò)程。FBXO3屬于Fbxs類，包含不同的蛋白質(zhì)-蛋白質(zhì)相互作用模塊或無(wú)可識(shí)別基序。FBXO3具有多種生物學(xué)功能，包括調(diào)節(jié)免疫病理、神經(jīng)性疾病和抗病毒反應(yīng)。FBXO3在炎癥性疾病和人類惡性腫瘤中的作用尤為重要，包括類風(fēng)濕性關(guān)節(jié)炎、白血病、垂體腺瘤和口腔鱗狀細(xì)胞癌。FBXO3通過(guò)泛素化和降解特定底物來(lái)調(diào)節(jié)多種細(xì)胞功能，成為治療包括癌癥在內(nèi)的多種疾病的新靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human F-box only protein 3 (FBXO3) (CSB-YP892132HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FBXO3 Antibody (CSB-PA892132LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U251 whole cell lysate(30μg), A431 whole cell lysate(30μg), A549 whole cell lysate(30μg), SY5Y whole cell lysate(30μg), HepG2 whole cell lysate(30μg), Hela whole cell lysate(30μg),Mouse Liver tissue lysate(30μg),Mouse Lung tissue lysate(30μg),Mouse Kidney tissue lysate(30μg)
All lanes: FBXO3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 55,48,47 kDa
Observed band size: 55 kDa
Exposure time: 60s
FBXO3 Antibodies
FBXO3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008495GA01HU | FBXO3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA892132LA01HU | FBXO3 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA892132LB01HU | FBXO3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA892132LC01HU | FBXO3 Antibody, FITC conjugated | Human | |
| CSB-PA892132LD01HU | FBXO3 Antibody, Biotin conjugated | Human | ELISA |
FBXO3 Proteins
FBXO3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP892132HU | Recombinant Human F-box only protein 3 (FBXO3) | Yeast |
| CSB-EP892132HU CSB-BP892132HU CSB-MP892132HU CSB-EP892132HU-B |
Recombinant Human F-box only protein 3 (FBXO3) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
