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DNAJC3

DnaJ homolog subfamily C member 3 is a protein in humans that is encoded by DNAJC3 gene. Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.

DNAJC3 Antibodies

DNAJC3 for Homo sapiens (Human)

DNAJC3 Proteins

DNAJC3 Proteins for Homo sapiens (Human)

DNAJC3 Proteins for Bos taurus (Bovine)

DNAJC3 Proteins for Dictyostelium discoideum (Slime mold)

DNAJC3 Proteins for Gallus gallus (Chicken)

DNAJC3 Proteins for Mus musculus (Mouse)

DNAJC3 Proteins for Rattus norvegicus (Rat)



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