CFI
CFI，全稱為補體因子I，常見別名FI，是人體補體系統(tǒng)里的關鍵調(diào)控者，像一道“安全閥”防止補體過度激活。它能精準作用于補體激活產(chǎn)生的C3b、C4b等活性成分，讓這些分子失去繼續(xù)觸發(fā)下游反應的能力，從而避免補體系統(tǒng)誤攻擊自身健康細胞。
CFI功能異常會引發(fā)多種疾?。夯钚圆蛔銜r，補體易失控激活，可能導致年齡相關性黃斑變性（尤其是濕性AMD）、非典型溶血尿毒綜合征（aHUS）、致密物沉積病等；活性過強則可能降低機體清除病原體的能力。目前針對CFI的藥物研發(fā)正穩(wěn)步推進，例如部分CFI抑制劑已進入臨床試驗，用于緩解濕性AMD患者視網(wǎng)膜的炎癥損傷；同時增強CFI活性的候選藥物也在探索中，有望改善補體缺陷相關的感染易感性問題。
熱銷產(chǎn)品
Recombinant Human Complement factor I (CFI), partial (CSB-EP005279HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CFI Antibody (CSB-PA005279LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: HepG2 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate
All lanes: CFI antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66 kDa
Observed band size: 66 kDa
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA005279LA01HU at dilution of 1:100
Human complement factor I(CFI) ELISA Kit (CSB-E13108h)
驗證數(shù)據(jù)
貨號：CSB-E13108h
規(guī)格：96T/48T
靈敏度：1.56 ng/mL
檢測范圍：6.25 ng/mL-400 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CFI Antibodies
CFI for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA564820 | CFI Antibody | Human | ELISA,WB |
| CSB-PA009441 | CFI Antibody | Human | WB, ELISA |
| CSB-PA005279LA01HU | CFI Antibody | Human | ELISA, WB, IHC |
| CSB-PA005279LB01HU | CFI Antibody, HRP conjugated | Human | ELISA |
CFI Proteins
CFI Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005279HU CSB-BP005279HU CSB-EP005279HU-B |
Recombinant Human Complement factor I (CFI) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP005279HU1 | Recombinant Human Complement factor I (CFI), partial | E.coli |
| CSB-EP005279HU | Recombinant Human Complement factor I (CFI) | E.coli |
| CSB-MP005279HU | Recombinant Human Complement factor I (CFI) | Mammalian cell |
| CSB-MP005279HUb0 | Recombinant Human Complement factor I (CFI) | Mammalian cell |
CFI Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005279MO1 CSB-EP005279MO1 CSB-EP005279MO1-B |
Recombinant Mouse Complement factor I (Cfi), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP005279MO | Recombinant Mouse Complement factor I (Cfi) | Baculovirus |
| CSB-MP005279MO | Recombinant Mouse Complement factor I (Cfi) | Mammalian cell |
CFI Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005279PYX CSB-EP005279PYX CSB-BP005279PYX CSB-MP005279PYX CSB-EP005279PYX-B |
Recombinant Pongo abelii Complement factor I (CFI) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFI Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005279RA CSB-EP005279RA CSB-EP005279RA-B |
Recombinant Rat Complement factor I (Cfi) | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP005279RA | Recombinant Rat Complement factor I (Cfi) | Baculovirus |
| CSB-MP005279RA | Recombinant Rat Complement factor I (Cfi) | Mammalian cell |
CFI ELISA Kit
CFI ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13108h | Human complement factor I(CFI) ELISA Kit | serum, plasma, tissue homogenates | 1.56 ng/mL |
CFI ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005279MO | Mouse Complement factor I(CFI) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.195 ng/mL |
