C6

C6全稱(chēng)為補(bǔ)體成分6，是補(bǔ)體系統(tǒng)終末通路的核心分子之一，負(fù)責(zé)與C5b、C7-C9共同組裝成膜攻擊復(fù)合物，直接破壞病原體或異常細(xì)胞的脂質(zhì)膜結(jié)構(gòu)。該蛋白先天性缺陷患者易反復(fù)感染腦膜炎奈瑟菌或淋球菌，部分研究還發(fā)現(xiàn)其水平異常與妊娠期高血壓、非典型溶血尿毒綜合征等疾病相關(guān)。在自身免疫領(lǐng)域，C6過(guò)度激活可能導(dǎo)致補(bǔ)體介導(dǎo)的血管內(nèi)皮損傷，與抗磷脂抗體綜合征等病理過(guò)程存在關(guān)聯(lián)。
目前針對(duì)補(bǔ)體系統(tǒng)的藥物開(kāi)發(fā)多聚焦于上游成分（如C5抑制劑依庫(kù)珠單抗），而直接靶向C6的療法仍屬空白。2021年有研究報(bào)道了一種特異性阻斷C6功能的人源化抗體，在體外實(shí)驗(yàn)中可抑制補(bǔ)體終末通路引發(fā)的溶血反應(yīng)，但尚未推進(jìn)至臨床。近年發(fā)現(xiàn)某些海洋生物毒素能選擇性干擾C6與其他補(bǔ)體蛋白的結(jié)合，為開(kāi)發(fā)新型免疫調(diào)節(jié)劑提供了線索，其轉(zhuǎn)化應(yīng)用仍需長(zhǎng)期驗(yàn)證。

熱銷(xiāo)產(chǎn)品

C6 Antibody (CSB-PA004036LA01HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: C6 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 105 kDa
Observed band size: 105 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004036LA01HU at dilution of 1:100

Human Complement component C6(C6) ELISA kit (CSB-EL004036HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL004036HU

規(guī)格：96T/48T

靈敏度：15.6 pg/mL

檢測(cè)范圍：62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

C6 Antibody

C6 Protein

C6 ELISA Kit

C6 Antibodies

C6 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA001093	C6 Antibody	Human,Rat	WB, IHC, ELISA
CSB-PA004036LA01HU	C6 Antibody	Human, Mouse, Rat	ELISA, WB, IHC
CSB-PA004036LB01HU	C6 Antibody, HRP conjugated	Human	ELISA
CSB-PA004036LD01HU	C6 Antibody, Biotin conjugated	Human	ELISA

C6 Proteins

C6 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP004036HU CSB-EP004036HU CSB-BP004036HU CSB-MP004036HU CSB-EP004036HU-B	Recombinant Human Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP004036EQV CSB-EP004036EQV CSB-BP004036EQV CSB-MP004036EQV CSB-EP004036EQV-B	Recombinant Pan troglodytes Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Pongo pygmaeus (Bornean orangutan)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP004036EXP CSB-EP004036EXP CSB-BP004036EXP CSB-MP004036EXP CSB-EP004036EXP-B	Recombinant Pongo pygmaeus Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP645889BO CSB-EP645889BO CSB-BP645889BO CSB-MP645889BO CSB-EP645889BO-B	Recombinant Bovine Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP770520RA CSB-EP770520RA CSB-BP770520RA CSB-MP770520RA CSB-EP770520RA-B	Recombinant Rat Complement component C6 (C6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

C6 Proteins for Subterranean clover stunt virus (strain F) (SCSV)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP774843SHAO CSB-EP774843SHAO CSB-BP774843SHAO CSB-MP774843SHAO CSB-EP774843SHAO-B	Recombinant Subterranean clover stunt virus Para-Rep C6 (C6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli