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ADAM8

ADAM8,全稱為A Disintegrin and metalloproteinase domain-containing protein 8,是一種在人類中由ADAM8基因編碼的酶。它也被稱為CD156、CD156a、MS2或ADAM metallopeptidase domain 8。ADAM8屬于ADAMs家族成員,具有蛋白水解酶活性,能夠水解并釋放多種細(xì)胞表面蛋白的胞外功能區(qū),進(jìn)而影響多種細(xì)胞因子功能并參與細(xì)胞外基質(zhì)的降解。ADAM8的表達(dá)最初發(fā)現(xiàn)于巨噬細(xì)胞,隨后相繼發(fā)現(xiàn)在人B淋巴細(xì)胞、樹突狀細(xì)胞、神經(jīng)膠質(zhì)細(xì)胞及人嗜酸性粒細(xì)胞等細(xì)胞內(nèi)均有表達(dá)。
ADAM8的異常表達(dá)與多種惡性腫瘤的轉(zhuǎn)移密切相關(guān),如肺癌、乳腺癌、胰腺癌、肝癌等。研究表明,ADAM8過表達(dá)可減弱腫瘤細(xì)胞間的黏附作用,并促進(jìn)細(xì)胞外基質(zhì)降解和細(xì)胞膜上細(xì)胞因子的釋放,同時有助于腫瘤部位新生血管生成,從而促進(jìn)了腫瘤細(xì)胞的轉(zhuǎn)移。因此,ADAM8成為惡性腫瘤的預(yù)后指標(biāo)和潛在治療靶點,備受關(guān)注。目前,ADAM8在腫瘤治療中的應(yīng)用前景主要有兩個方面:一是作為生物標(biāo)志物,檢測ADAM8的表達(dá)可以反映腫瘤狀態(tài),有效預(yù)測患者預(yù)后;二是作為藥物設(shè)計的靶標(biāo),使用ADAM8選擇性抑制劑抑制ADAM8可能會產(chǎn)生較好的治療作用。

熱銷產(chǎn)品

ADAM8 Antibody (CSB-PA10259A0Rb)

驗證數(shù)據(jù)

CSB-PA10259A0Rb

Western Blot
Positive WB detected in: THP-1 whole cell lysate(20μg), K562 whole cell lysate(20μg), JK whole cell lysate(20μg)
All lanes: ADAM8 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 79,81 kDa
Observed band size: 100 kDa
Exposure time: 300s

CSB-PA10259A0Rb

ImmunofluorescencestainingofHelacellwithCSB-PA10259A0Rbat1:30,counter-stainedwithDAPI.Thecellswerefixedin4%formaldehydeandblockedin10%normalGoatSerum.Thecellswerethenincubatedwiththeantibodyovernightat4C.ThesecondaryantibodywasAlexaFluor488-congugatedAffiniPureGoatAnti-RabbitIgG(H+L).

CSB-PA10259A0Rb

Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA10259A0Rb

Immunofluorescence staining of MCF-7 cell with CSB-PA10259A0Rb at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA10259A0Rb

ImmunofluorescencestainingofMCF-7cellwith5%goatserum,counter-stainedwithDAPI.Thecellswerefixedin4%formaldehydeandblockedin10%normalGoatSerum.Thecellswerethenincubatedwiththeantibodyovernightat4C.ThesecondaryantibodywasAlexaFluor488-congugatedAffiniPureGoatAnti-RabbitIgG(H+L).

ADAM8 Antibodies

ADAM8 for Homo sapiens (Human)

ADAM8 Proteins

ADAM8 Proteins for Homo sapiens (Human)



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