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IFNGR1

IFNGR1,全稱為干擾素γ受體1,常用別名包括CD119。它是存在于細胞膜表面的受體分子,可與干擾素γ特異性結合,參與調控機體免疫應答:通過這一結合,能推動免疫細胞的活化與功能發揮,助力清除病原體如分枝桿菌、病毒等。
IFNGR1功能異常,機體對特定病原體的抵抗力會降低,比如引發常染色體隱性遺傳的免疫缺陷病,患者易反復出現嚴重分枝桿菌感染或機會性感染。此外,其表達或活性異常也可能與自身免疫病、腫瘤相關——部分自身免疫病中,它的信號紊亂可能加重免疫細胞對自身組織的損傷;某些腫瘤里,它的異常可能影響免疫細胞對腫瘤細胞的識別與清除。目前針對該蛋白的藥物研發集中在免疫調節方向,一些候選藥物嘗試通過調控其活性治療感染性疾病或自身免疫病,部分已進入臨床前或早期臨床研究階段,期望調整免疫平衡改善疾病狀態。

熱銷產品

Recombinant Human Interferon gamma receptor 1 (IFNGR1), partial (CSB-MP011051HU1d7)

驗證數據

CSB-MP011051HU1d7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IFNGR1 Recombinant Monoclonal Antibody (CSB-RA234462A0HU)

驗證數據

CSB-RA234462A0HU

Flow cytometric analysis of Interferon gamma receptor 1 expression in C2C12 cells using Interferon gamma receptor 1 antibody. Green, isotype control; red, Interferon gamma receptor 1.

CSB-RA234462A0HU

Immunocytochemical staining of C2C12 cells with Interferon gamma receptor 1 antibody. Nuclei were stained blue with DAPI; Interferon gamma receptor 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

CSB-RA234462A0HU

Western blotting analysis using interferon gamma receptor 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with interferon gamma receptor 1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.

IFNGR1 Antibody (CSB-PA011051DSR2HU)

驗證數據

CSB-PA011051DSR2HU

Western blot
All lanes: IFNGR1 antibody at 2μg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55, 22 kDa
Observed band size: 55 kDa

IFNGR1 Antibodies

IFNGR1 for Homo sapiens (Human)

IFNGR1 Proteins

IFNGR1 Proteins for Mus musculus (Mouse)

IFNGR1 Proteins for Homo sapiens (Human)



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