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  4. VSIR (KVA-12.1 Biosimilar) Recombinant Monoclonal Antibody

VSIR (KVA-12.1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA884484MB2HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    VSIR (KVA-12.1 Biosimilar Antibody)重組單克隆抗體是一款針對VSIR靶點研發的生物工程抗體產品，專為科研用途設計。該抗體通過重組DNA技術在哺乳動物細胞表達系統中制備，具有高純度、高特異性和批次間一致性等特點，為免疫學、腫瘤學等領域的基礎研究及藥物開發提供有力工具。 作為靶向VSIR的單克隆抗體，其核心優勢在于能夠特異性識別并結合VSIR蛋白，從而深入探究該免疫檢查點分子在免疫調節中的作用機制。VSIR作為近年來發現的重要免疫調節靶點，在T細胞活化、免疫耐受維持及腫瘤微環境調控中扮演關鍵角色。通過使用該抗體，研究人員可在體外細胞模型及動物模型中開展VSIR信號通路解析、受體-配體相互作用分析、免疫細胞功能調控某些實驗，為揭示免疫相關疾病的發病機制提供重要實驗依據。 產品采用嚴格的生產工藝和質量控制標準，確保抗體的生物學活性和結構完整性。其應用場景廣泛，包括但不限于、功能性細胞實驗等，滿足不同研究方向的技術需求。此外，該抗體經過優化的配方設計，可在-20℃條件下長期穩定保存，有效保障實驗結果的可重復性與可靠性。 VSIR (KVA-12.1 Biosimilar Antibody)重組單克隆抗體的開發為科研人員提供了高質量的研究工具，助力深入探索VSIR靶點的生物學功能及潛在的臨床應用價值，推動相關領域的科學研究進展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    KVA12.1 research-grade biosimilar; KVA 12.1 research-grade biosimilar; KVA-12.1 research-grade biosimilar; KVA12123 research-grade biosimilar; TBS-2025 research-grade biosimilar ;VSIR antibody; C10orf54 antibody; SISP1 antibody; VISTA antibody; PP2135 antibody; UNQ730/PRO1412 antibody; V-type immunoglobulin domain-containing suppressor of T-cell activation antibody; Platelet receptor Gi24 antibody; Stress-induced secreted protein-1 antibody; Sisp-1 antibody; V-set domain-containing immunoregulatory receptor antibody; V-set immunoregulatory receptor antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human VSIR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
  • 基因功能參考文獻：
    1. Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
    2. High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
    3. VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
    4. This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
    5. Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
    6. this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
    7. overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
    8. p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
    9. Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
  • 數據庫鏈接：

    HGNC: 30085

    OMIM: 615608

    KEGG: hsa:64115

    STRING: 9606.ENSP00000378409

    UniGene: Hs.47382



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