TYRP1 (Flanvotumab Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA025399MB1HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:20D7 research-grade biosimilar; 20-D-7 research-grade biosimilar; 20D7S research-grade biosimilar; 20-D-7-S research-grade biosimilar; Flanvotumab (USAN) research-grade biosimilar; IMC 20D7S research-grade biosimilar; IMC-20D7S research-grade biosimilar; IMC-20-D-7-S research-grade biosimilar; TYRP1 antibody; CAS2 antibody; TYRP antibody; TYRRP antibody;5,6-dihydroxyindole-2-carboxylic acid oxidase antibody; DHICA oxidase antibody; EC 1.14.18.- antibody; Catalase B antibody; Glycoprotein 75 antibody; Melanoma antigen gp75 antibody; Tyrosinase-related protein 1 antibody; TRP antibody; TRP-1 antibody; TRP1 antibody
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反應種屬:Human
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免疫原:Recombinant Human TYRP1 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
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基因功能參考文獻:
- The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype. PMID: 26450459
- TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA. PMID: 28991221
- The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. PMID: 29087386
- DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively. PMID: 28186599
- Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma. PMID: 25837821
- Mutation in TYRP1 is associated with oculocutaneous albinism. PMID: 26252096
- Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity PMID: 26068396
- These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner. PMID: 25240771
- These data indicate that galectin-3 is a regulatory component in melanin synthesis affecting the expression of Tyrp-1. PMID: 25054620
- p53 regulation by TRP2 is not pervasive in melanoma. PMID: 24475287
- Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III. PMID: 23862152
- in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. PMID: 23416839
- High TYRP1/S100B mRNA expression in lymph node metastases from melanoma patients is associated with unfavourable clinical outcome. PMID: 23519055
- We report four Pakistani albinism mutations, including three SLC45A2 alleles and one 22-nucleotide deletion in TYRP1. PMID: 23190901
- identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance PMID: 22556244
- We used the first ranked gene, tyrosinase-related protein 1 (TYRP1), further measured its expression in the validation population by real-time PCR and found it to be significantly correlated with distant metastasis-free survival. PMID: 22045183
- two novel mutations in TYRP1 gene in two Chinese patients with oculocutaneous albinism type 3 PMID: 21739261
- Case Report: Report a Japanese girl with oculocutaneous albinism type 3 and novel mutations in TYRP1 gene. PMID: 21996312
- This review focuses on TYRP1, a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging roles in the malignant melanocyte and melanoma progression. PMID: 21324755
- interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
- Adoptive transfer of TRP1-specific T cells into -expressing recipients produces large confluent patches of vitiligo and ocular damage in TRP1-specific T cell receptor transgenic mice. PMID: 20668223
- Tyrp1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and melanocyte cell death. PMID: 11775055
- DNA sequence variants in the human TYRP1 gene are not associated with inherited pigmentary glaucoma in humans. PMID: 12011806
- We have identified the first TYRP1 mutation in non-Africans and have confirmed that TYRP1 mutations are associated with a milder phenotype of oculocutaneous albinism. PMID: 15996218
- The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE. PMID: 16934245
- Melanocytes in vitiligo demonstrate reduced ability to withstand oxidative stress due, partly, to a disruption in microphthalmia-associated transcription factor regulation of Tyrp1. PMID: 17071589
- We observe strong evidence for positive selection for TYRP1 alleles in Africans and in Asians PMID: 18312627
- An eye color variant in TYRP1 was associated with risk of cutaneous melanoma. PMID: 18488027
- Mutation of TYRP1 (OCA3) can modify the OCA2 phenotype, resulting in red hair. PMID: 18680187
- Both TRP-1 and galectin-1 were highly expressed in normal melanocytes and melanoma. There was no correlation between TRP-1 or galectin-1 expression and survival. PMID: 19287070
- TYRP1 rs1408799 is associated with melanoma. PMID: 19384953
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相關(guān)疾病:Albinism, oculocutaneous, 3 (OCA3)
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亞細胞定位:Melanosome membrane; Single-pass type I membrane protein. Melanosome.
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蛋白家族:Tyrosinase family
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組織特異性:Pigment cells.
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