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  4. TAFA5 (NS-101 Biosimilar) Recombinant Monoclonal Antibody

TAFA5 (NS-101 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA773595MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    TAFA5 (NS-101 Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物試劑，具有高度特異性和生物學活性。該產品通過重組DNA技術制備，能夠精準識別并結合靶分子，為生命科學研究提供可靠的工具支持。 在結構設計上，TAFA5重組單克隆抗體采用單克隆抗體的經典分子結構，具有均一性高、批次穩定性好的特點。其可變區經過優化設計，可特異性靶向特定抗原表位，有效避免非特異性結合，確保實驗結果的準確性和可重復性。 該抗體適用于多種實驗場景，包括但不限于、酶聯免疫吸附測定（ELISA）等。在基礎研究中，可用于蛋白質定位分析、信號通路調控機制探討、疾病相關分子的功能驗證等方向；在藥物研發前期研究中，可助力靶點驗證、藥效篩選及作用機制研究等環節。 TAFA5重組單克隆抗體制備過程嚴格遵循GMP級質量管理體系，從細胞培養、蛋白表達、純化到最終制劑，均采用標準化操作流程。產品經過多項質控檢測，包括純度分析、活性驗證、內毒素控制及無菌性檢查等，確保符合科研實驗的高標準要求。 作為科研用生物試劑，TAFA5重組單克隆抗體為研究人員提供了高質量的實驗材料，有助于推動免疫學、細胞生物學、分子生物學等領域的基礎研究和應用探索，為生命科學領域的創新發展提供有力支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    NS101(Neuracle Science) research-grade biosimilar; RY103 research-grade biosimilar; RY-103 research-grade biosimilar ;TAFA5 antibody; FAM19A5 antibody; UNQ5208/PRO34524 antibody; Chemokine-like protein TAFA-5 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TAFA5 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    FAM19/TAFA family
  • 組織特異性：
    Expressed in the subcutaneous and perirenal adipose tissue (at protein level). Highly expressed in adipose tissue with moderate expression in the brain and ovary. Isoform 2: Brain-specific.
  • 數據庫鏈接：

    HGNC: 21592

    OMIM: 617499

    KEGG: hsa:25817

    STRING: 9606.ENSP00000383933

    UniGene: Hs.436854



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