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  4. SIGLEC6 (AK-006 Biosimilar) Recombinant Monoclonal Antibody

SIGLEC6 (AK-006 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA021300MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    SIGLEC6 (AK-006 Biosimilar Antibody)重組單克隆抗體是一款專為生命科學研究設計的高精度實驗工具。該抗體以SIGLEC6蛋白為靶向目標，通過重組DNA技術在哺乳動物細胞中表達制備，具有高特異性和高親和力的特性。 SIGLEC6屬于唾液酸結合免疫球蛋白樣凝集素家族成員，在多種生理和病理過程中發揮關鍵調控作用，包括細胞黏附、信號轉導及免疫調節等。本產品為科研人員提供了可靠的研究工具，可廣泛應用于等多種實驗場景，助力深入探究SIGLEC6在細胞生物學、分子免疫學及相關疾病機制中的功能。 產品采用嚴格的質量控制標準，通過多輪純化工藝確保低內毒素水平和高純度，批間一致性良好。其重組表達體系不僅保證了抗體結構的正確折疊，還可實現穩定的規模化生產，滿足不同實驗需求。該抗體適用于人源及部分動物源樣本的檢測分析，為生命科學領域的基礎研究和藥物研發提供重要支持。 作為科研級試劑，本產品僅供實驗室研究使用，不可用于臨床診斷或治療用途。通過特異性識別SIGLEC6靶點，可幫助研究團隊揭示該分子在疾病發生發展中的作用機制，為開發新型靶向治療策略提供實驗依據。
  • Uniprot No.：
  • 基因名：
  • 別名：
    AK006 research-grade biosimilar; AK 006 research-grade biosimilar ;SIGLEC6 antibody; CD33L antibody; CD33L1 antibody; OBBP1 antibody; Sialic acid-binding Ig-like lectin 6 antibody; Siglec-6 antibody; CD33 antigen-like 1 antibody; CDw327 antibody; Obesity-binding protein 1 antibody; OB-BP1 antibody; CD antigen CD327 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SIGLEC6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems. Guaranteed Quality ① Antibody purity?> 95% tested by SDS-PAGE. ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 基因功能參考文獻：
    1. Siglec6 and leptin play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion. PMID: 23089140
    2. Siglec-6 expression is increased in preterm preeclampsia placentas. PMID: 23171684
    3. GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway. PMID: 21880722
    4. the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process PMID: 17580316
    5. Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts. PMID: 18818296

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  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
  • 數據庫鏈接：

    HGNC: 10875

    OMIM: 604405

    KEGG: hsa:946

    STRING: 9606.ENSP00000401502

    UniGene: Hs.720304



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