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  4. SERPINF2 (BAY-3018250 Biosimilar) Recombinant Monoclonal Antibody

SERPINF2 (BAY-3018250 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA021085MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    SERPINF2 (BAY-3018250 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途設計的生物試劑。該抗體以SERPINF2蛋白為靶點，通過重組DNA技術在體外表達制備，具有高特異性和高親和力的特點，為相關領域的科學研究提供了可靠的工具。 SERPINF2基因編碼的蛋白質屬于絲氨酸蛋白酶抑制劑超家族，在機體的凝血、纖溶等生理過程中發揮重要調控作用。本產品作為針對該靶點的單克隆抗體，可廣泛應用于蛋白質印跡、酶聯免疫吸附測定（ELISA）等多種實驗技術，助力研究人員深入探索SERPINF2蛋白的分子功能、表達模式及其在疾病發生發展中的作用機制。 該重組單克隆抗體采用標準化的生產工藝，確保了批次間的穩定性和一致性。其高度純化的特性有效降低了非特異性結合，提升了實驗結果的準確性和可重復性。通過特異性識別SERPINF2蛋白，研究人員能夠實現對目標蛋白的定性檢測、定量分析及亞細胞定位等研究目標，為闡明相關生理病理過程提供關鍵實驗數據。 作為科研工具，SERPINF2 (BAY-3018250 Biosimilar Antibody)重組單克隆抗體適用于基礎醫學、生物化學、分子生物學等領域的研究工作，為揭示SERPINF2相關信號通路及疾病機制提供有力支持，推動相關領域的科學發現和技術創新。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BAY3018250 research-grade biosimilar; BAY 3018250 research-grade biosimilar ;SERPINF2 antibody; AAP antibody; PLI antibody; Alpha-2-antiplasmin antibody; Alpha-2-AP antibody; Alpha-2-plasmin inhibitor antibody; Alpha-2-PI antibody; Serpin F2 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SERPINF2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
  • 基因功能參考文獻：
    1. alpha2AP has a profibrotic effect probably not by the action as a plasmin inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis PMID: 26743600
    2. This review presents recent findings regarding the main aspects of the natural heterogeneity of A2AP with particular focus on the functional and possible clinical implications. [review] PMID: 26626994
    3. Possession of the alpha2AP 407Lys allele was negatively associated with AAA, and thus changes in alpha2AP may affect aneurysm growth and development. PMID: 25065555
    4. Changes in plasma A2AP are associated with cardiovascular disease event presentation. PMID: 26088309
    5. A significant correlation was found between soluble fibroblast activation protein levels and alpha2-antiplasmin cleavage in coronary thrombosis. PMID: 25464232
    6. increased N-terminal cleavage of alpha2AP may have a role in liver cirrhosis PMID: 24034420
    7. FXIII-A has a functional role through exposure on the activated platelet membrane where it exerts antifibrinolytic function by cross-linking alpha2AP to fibrin PMID: 25331118
    8. Data suggest serum A2AP (SERPINF2) level can serve as biomarker for diabetic retinopathy; levels of A2AP (but not fibrinogen, plasminogen, or plasminogen activator inhibitor 1) are up-regulated in hyperglycemic type 1 diabetes with retinopathy. PMID: 24818165
    9. protective mediator during gram-negative (pneumo)sepsis, limiting bacterial growth, inflammation, tissue injury, and coagulation PMID: 23992406
    10. Study revealed that plasmin was present in tumor tissue, and that it was responsible for processing progalanin to galanin(1-20) in the extracellular environment. PMID: 21707521
    11. Data suggest that decreased amounts of alpha2-plasmin inhibitor in plasma vs serum ex vivo may reflect reduced factor XIII (FXIII) in vivo; thus, plasma vs serum alpha2-plasmin inhibitor may be useful diagnostic marker for severe FXIII deficiency. PMID: 22205503
    12. fibrinolysis is enhanced by inhibiting enzymatic cleavage of precursor alpha2-antiplasmin PMID: 21251197
    13. Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. PMID: 21486949
    14. Levels of free full-length alpha2AP were decreased in myocardial infarction (MI); the percentage of C-terminally cleaved alpha2AP was unaltered, and Arg407Lys did not influence alpha2AP levels or MI risk. PMID: 21505192
    15. the antifibrinolytic function of FXIII is independent of fibrin-fibrin cross-linking and is expressed exclusively through alphaAP. PMID: 21471521
    16. ADAMTS13 inactivation by plasmin as a potential cause of thrombotic thrombocytopenic purpura PMID: 20553378
    17. deficiency in patients with Philadelphia chromosome-positive haematologic cancer receiving imatinib mesylate PMID: 19492163
    18. OPN is highly susceptible to cleavage near its integrin-binding motifs, and the protein is a novel substrate for plasmin and cathepsin D PMID: 20071328
    19. FXIIIa substrate, A2AP, sequences suggests that the residue located two positions beyond the reactive glutamine is not conserved. this position makes important contributions to effective FXIIIa-A2AP interactions PMID: 19691486
    20. Multiple Lys residues within alpha 2-antiplasmin contribute, perhaps in a zipper-like fashion, to its binding to the in-tandem, multikringle array that configures the plasmin heavy chain. PMID: 12549929
    21. Alpha2-antiplasmin has an important role in acute pulmonary embolism PMID: 12911586
    22. the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin PMID: 17317851
    23. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate PMID: 17883703
    24. Hydroxyethyl starch (HES) dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. PMID: 17890952
    25. Sequencing analysis revealed the presence of two alpha2-PI gene variations, both in the second half of exon 10: a frameshift mutation and a G to A transition at nucleotide 11337 in codon 407. PMID: 17961166
    26. Thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin are not markers for recanalization in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. PMID: 18048863
    27. Plasmin in nephrotic urine activates the epithelial sodium channel PMID: 19073825

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  • 相關疾病：
    Alpha-2-plasmin inhibitor deficiency (APLID)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數據庫鏈接：

    HGNC: 9075

    OMIM: 262850

    KEGG: hsa:5345

    STRING: 9606.ENSP00000321853

    UniGene: Hs.159509



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