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  4. PVRIG (GSK-4381562 Biosimilar) Recombinant Monoclonal Antibody

PVRIG (GSK-4381562 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA721905MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    PVRIG (GSK-4381562 Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物試劑，專為研究程序性死亡受體1（PD-1）通路相關(guān)免疫調(diào)節(jié)機(jī)制而開(kāi)發(fā)。該抗體通過(guò)基因工程技術(shù)制備，具有高度的靶向特異性，能夠精準(zhǔn)識(shí)別并結(jié)合PVRIG（脊髓灰質(zhì)炎病毒受體相關(guān)免疫球蛋白結(jié)構(gòu)域蛋白），從而為探索腫瘤微環(huán)境中的免疫抑制通路提供關(guān)鍵工具。 作為研究用試劑，該抗體可應(yīng)用于多種實(shí)驗(yàn)場(chǎng)景，包括但不限于細(xì)胞水平的受體結(jié)合分析、共定位、檢測(cè)以及體外功能性實(shí)驗(yàn)等。其重組表達(dá)工藝確保了批次間的穩(wěn)定性和高純度，有助于提升實(shí)驗(yàn)結(jié)果的可靠性與可重復(fù)性。研究人員可借助該抗體深入探究PVRIG與PVRL2等配體的相互作用機(jī)制，以及其在腫瘤免疫逃逸中的調(diào)控作用，為開(kāi)發(fā)新型免疫治療策略提供理論依據(jù)。 該產(chǎn)品嚴(yán)格用于科研用途，不適用于臨床診斷或治療。在使用過(guò)程中，建議根據(jù)具體實(shí)驗(yàn)需求優(yōu)化抗體濃度和孵育條件，以獲得最佳檢測(cè)效果。通過(guò)特異性阻斷PVRIG信號(hào)通路，該抗體有望助力揭示免疫檢查點(diǎn)分子的協(xié)同調(diào)控網(wǎng)絡(luò)，為腫瘤免疫學(xué)及相關(guān)領(lǐng)域的基礎(chǔ)研究和藥物開(kāi)發(fā)提供重要支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    GSK4381562 research-grade biosimilar; GSK 4381562 research-grade biosimilar; GSK4381562A research-grade biosimilar; GSK562 research-grade biosimilar; SRF813 research-grade biosimilar; SRF-813 research-grade biosimilar ;PVRIG antibody; C7orf15 antibody; Transmembrane protein PVRIG antibody; CD112 receptor antibody; CD112R antibody; Poliovirus receptor-related immunoglobulin domain-containing protein antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PVRIG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
  • 基因功能參考文獻(xiàn)：
    1. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
    2. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 32190

    OMIM: 617012

    KEGG: hsa:79037

    STRING: 9606.ENSP00000316675

    UniGene: Hs.729356



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