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PTP4A3 (PRL3-zumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA019014MB1HU
  • 規格:
    ¥83486
  • 其他:

產品詳情

  • 產品描述:
    PTP4A3 (PRL3-zumab Biosimilar Antibody)重組單克隆抗體是一種針對PTP4A3(又稱為PRL3)靶點的生物制劑,主要用于生命科學研究領域。該抗體通過基因工程技術制備,具有高特異性和親和力,能夠精準識別并結合PTP4A3蛋白,為相關機制研究提供有力工具。 PTP4A3屬于蛋白酪氨酸磷酸酶家族成員,在多種生理和病理過程中發揮重要作用,尤其與腫瘤的發生發展密切相關。作為科研用試劑,該抗體可應用于某些實驗,助力研究人員探索PTP4A3的表達模式、亞細胞定位及其在信號通路中的調控機制。 該重組單克隆抗體采用CHO細胞或其他真核表達系統生產,經過嚴格的純化和質量控制,確保產品批次間的穩定性和實驗結果的可靠性。其高純度特性可有效減少非特異性結合,提高實驗數據的準確性,適用于細胞生物學、分子生物學及基礎醫學等研究方向。 通過使用PTP4A3 (PRL3-zumab Biosimilar Antibody)重組單克隆抗體,科研人員能夠深入研究PTP4A3在疾病模型中的功能,為揭示相關疾病的發病機制提供關鍵實驗材料,推動靶向治療策略的前期研究與開發。該產品僅用于實驗室研究,不用于臨床診斷或治療用途。
  • Uniprot No.:
  • 基因名:
  • 別名:
    PRL3 ZUMAB research-grade biosimilar ;PTP4A3 antibody; PRL3 antibody; Protein tyrosine phosphatase type IVA 3 antibody; EC 3.1.3.48 antibody; PRL-R antibody; Protein-tyrosine phosphatase 4a3 antibody; Protein-tyrosine phosphatase of regenerating liver 3 antibody; PRL-3 antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PTP4A3 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能:
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 基因功能參考文獻:
    1. PRL-3 may be a reliable biomarker for early prostate cancer detection and may provide a predictive indicator of tumor progression PMID: 29207031
    2. The proliferation and invasion of colorectal cancer cells were enhanced significantly by PRL-3 through improving glycolysis. PMID: 28791350
    3. We conclude that PRL-3 is an important regulatory factor for breast cancer cell proliferation and invasion. Loss of PRL-3 function induces an antimetastatic gene expression profile in breast cancer cells. Due to its role in tumor growth and metastasis, PRL-3 emerges as a new therapeutic target in breast cancer therapy. PMID: 28980126
    4. Since high PRL-3 expression also correlates with poor prognosis in other cancers and functional studies in PC support these findings, PRL-3 emerges as a potential treatment target in PC PMID: 29190795
    5. Data show that phosphatase of regenerating liver-3 (PRL-3a) is an important mediator of growth factor signaling in MM cells and hence possibly a good target for treatment of MM. PMID: 27036022
    6. Data suggest that phosphatase of regenerating liver-3 (PRL-3)might play a tumor suppressor role in lung cancer, distinct from other cancers, by inhibiting epithelial-mesenchymal transition (EMT)-related pathways. PMID: 26967563
    7. A novel role of PRL-3 in tumor development through its adverse impact on telomere homeostasis. PMID: 28482095
    8. our result indicated that PRL-3 promotes protein phosphorylation by acting as an 'activator kinase' and consequently regulates cytokine secretion. PMID: 28068414
    9. The disruption of epithelial architecture by PRL-3 revealed here is a newly recognized mechanism for PRL-3-promoted cancer progression. PMID: 27656108
    10. This study suggests PRL-3 and SFKs are key mediators of the IL6-driven signaling events. PMID: 27698077
    11. Regulation of PTP4A3 expression is altered in specific subgroups of acute leukemias and this is likely brought about by expression of the aberrant ETV6-RUNX1 and BCR-ABL1 fusion genes. PMID: 28063378
    12. PRL-3 engages the focal adhesion pathway in trip0le-negative breast cancer cells as a key mechanism for promoting TNBC cell migration and invasion. PMID: 27452906
    13. PTP4A3 regulated glioblastoma multiforme via miR-137-mediated Akt/mTOR signaling pathway. PMID: 27328425
    14. Studies suggest that transcriptional, translational, or posttranslational regulation might be involved in the aberrant expression of phosphatase of regenerating liver (PRL)-3. PMID: 27911713
    15. we observed that PRL-3 regulated the clustering of integrin beta1 in FAs on collagen I but not on fibronectin. This work identifies PRL-3 as a new regulator of cell adhesion structures to the extracellular matrix, and further supports PRL-3 as a key actor of metastasis in uveal melanoma, of which molecular mechanisms are still poorly understood PMID: 28284838
    16. PTP4A3 may play a role in bladder cancer oncogenesis and is a predictive marker of metastasis. PTP4A3 overexpression represents an independent prognosticator for BC, suggesting its potential theranostic value. PMID: 26433386
    17. our results provide a bridge between PRL-3 and PTEN; PRL-3 decreased the expression of PTEN as well as increased the level of PTEN phosphorylation and inactivated it, consequently activating the PI3K/Akt signaling pathway, and upregulating MMP-2/MMP-9 expression to promote gastric cancer cell peritoneal metastasis. PMID: 27572739
    18. PRL-3 promotes cell migration and invasion via the NF-kappaB-HIF-1alpha-miR-210 axis. High levels of PRL-3 and miR-210 are related with poor OS in gastric cancer. PMID: 26548949
    19. Data suggest that induction of PRL3 (phosphatase of regenerating liver-3) contributes to increased cytoskeleton reorganization, increased cell motility, and possibly increased invasiveness of endometrial stromal cells (ESC) from subjects with endometrioma as compared to ESC from normal subjects. PMID: 26874360
    20. Results uncovered that aberrant overexpression of PRL-3 could initiate chordoma in early development. PMID: 26846972
    21. Role of PRL-3 in the development, migration, and invasion of salivary adenoid cystic carcinoma (SACC). PMID: 26041460
    22. PRL-3 has a role in the pathogenesis of prostate cancer. PMID: 26975394
    23. PRL-3 provides a strategic survival advantage to tumour cells via its effects on mTOR. PMID: 26597054
    24. Promotes uveal melanoma aggressiveness via membrane accumulation of matrix metalloproteinase 14 (MMP14) PMID: 27096756
    25. Our findings suggested that PRL-3 genomic gain may represent an aggressive phenotype of primary colorectal cancer PMID: 26563151
    26. Examination of clinical samples confirmed that USP4 expression positively correlates with PRL-3 protein expression, but not mRNA transcript levels. PMID: 26669864
    27. PTP4A3 over expression independently predicted the metastasis and outcome of upper tract urothelial carcinoma, which was even more important in organ confined disease. PMID: 26070892
    28. Data inticate that heat shock protein 60 (HSP60) interacted constitutively with NKG2D ligand ULBP2 and phosphatase of regenerating liver 3 (PRL-3) regulated HSP60 tyrosine phosphorylation. PMID: 25687758
    29. These studies reveal a critical role of autophagy in PTP4A3-driven cancer progression. PMID: 25136802
    30. miR-495 methylation-associated silencing inhibits the migration and invasion of human gastric cancer cells by directly targeting PRL-3 PMID: 25475733
    31. Tumor-associated macrophages participate in the metastasis of CRC induced by PRL-3 through secretion of IL-6 and IL-8 in a KCNN4 dependent manner. PMID: 24885636
    32. STAT3 binds to the -201 to -210 region of PRL-3. STAT3 functionally regulates PRL-3. STAT3 core signature was enriched in AML with high PRL-3 expression. The STAT3/PRL-3 regulatory loop contributes to the pathogenesis of AML. PMID: 25139404
    33. The expression of PRL-3, but not of E-cadherin, was associated with shorter survival of patients. PRL-3 and E-cadherin exhibit interactions in gastric cancer and are involved in the formation of lymph node metastases PMID: 24696260
    34. Aberrant PRL-3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of Cyclin D1 and CDK2 and activation of STAT5 and AKT. PMID: 24737397
    35. PRL-3 and Leo1 levels were positively associated in AML patient samples. PMID: 24686170
    36. Studies indicate a significant association of phosphatase of regenerating liver 3 (PRL-3) overexpression with overall survival and some clinicopathological features in gastric cancer. PMID: 24204707
    37. PRL3 provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. PMID: 24030100
    38. The strong expression of PRL-3 in the primary tumor that was significantly correlated with the grade and clinical stage suggest that PTP4A3 participates in the process of endometrial carcinogenesis. PMID: 23729584
    39. PRL-3 induces microvascular vessel formation by facilitating VEGF expression in endometrial adenocarcinoma tissues PMID: 23989302
    40. These findings strongly support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis. PMID: 24403062
    41. Clinically, high PRL-3 mRNA expression was associated with FLT3-ITD mutations in four independent acute myeloid leukaemia datasets with 1158 patients. PMID: 23929599
    42. PRL-3 is phosphorylated downstream of Src, and this phosphorylation is required for PRL-3 to promote invasion, motility and activation of RhoC in cell culture systems. PMID: 23691193
    43. our findings demonstrate that PRL-3-targeted DNA vaccine can generate significantly preventive and therapeutic effects on the growth of breast cancer expressing PRL-3 through the induction of cellular immune responses to PRL-3 PMID: 23364316
    44. PRL-3-induced hyperactivation of EGFR correlates with increased cell growth, promigratory characteristics, and tumorigenicity in colorectal cancer. PMID: 23867504
    45. Explored the mechanism by which PRL-3 mediates EMT. Demonstrated that PRL-3 induced the expression of KCNN4 channels, leading to EMT and the down-regulation of E-cadherin. PMID: 23572150
    46. The ability of DHEA to target prenylation pathway could be utilized to inhibit PRL-3 prenylation for successful prevention of CRC metastases. PMID: 23462371
    47. PRL-3 plays a critical role in ovarian cancer tumorigenicity and maintaining the malignant phenotype. PRL-3 may inhibit c-fos transcriptional regulation of integrin alpha2 signaling. PMID: 23418787
    48. PRL-3 expression was related to LVI or necrosis which is important for tumor invasiveness, we could not find that PRL-3 as an important prognostic factor in breast cancer patient PMID: 22855168
    49. High expression of the PRL-3 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer. PMID: 22440248
    50. PRL-3 is a key regulator of histone demethylation. JMJD1B seems to be a candidate tumour suppressor and JMJD2B seems to be a potential oncoprotein in the development and progression of CRC. PMID: 22345654

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  • 亞細胞定位:
    Cell membrane. Early endosome.
  • 蛋白家族:
    Protein-tyrosine phosphatase family
  • 組織特異性:
    Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 數據庫鏈接:

    HGNC: 9636

    OMIM: 606449

    KEGG: hsa:11156

    STRING: 9606.ENSP00000332274

    UniGene: Hs.43666



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