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  4. PEAR1 (SV001 Biosimilar) Recombinant Monoclonal Antibody

PEAR1 (SV001 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA017765MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    PEAR1 (SV001 Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物制劑。該產品通過基因工程技術制備，具有高特異性和高親和力的特點。作為重組單克隆抗體，它能夠精準識別并結合目標抗原，為生命科學研究提供可靠的工具。 在科研應用中，PEAR1 (SV001) 可用于多種實驗場景，包括但不限于、。其高度均一的分子結構有助于提高實驗結果的重復性和準確性，為研究人員提供穩定的實驗數據支持。 該抗體的研發嚴格遵循生物制藥的生產標準，采用先進的生產工藝和質量控制體系，確保產品的批次間一致性和高純度。通過優化的表達系統和純化工藝，PEAR1 (SV001) 具有低內毒素水平和高活性，能夠滿足各種精密實驗的需求。 作為科研工具，PEAR1 (SV001 Biosimilar Antibody)重組單克隆抗體為生命科學領域的基礎研究和應用研究提供了有力支持，有助于推動相關領域的科學探索和技術創新。研究人員可根據具體實驗需求，合理設計實驗方案，充分發揮該抗體的性能優勢，為科學發現提供可靠的實驗依據。
  • Uniprot No.：
  • 基因名：
  • 別名：
    PEAR1 research-grade biosimilar; SV001 research-grade biosimilar; SV 001 research-grade biosimilar; SV-001 research-grade biosimilar ;PEAR1 antibody; MEGF12 antibody; Platelet endothelial aggregation receptor 1 antibody; hPEAR1 antibody; Multiple epidermal growth factor-like domains protein 12 antibody; Multiple EGF-like domains protein 12 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PEAR1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
  • 基因功能參考文獻：
    1. PEAR1 rs56260937 minor allele was an independent predictor of revascularization events. PMID: 29212986
    2. For Chinese patients with ACS treated with aspirin and clopidogrel, genetic mutations in rs822441/rs822442 in PEAR1 correlated significantly with platelet activity after adjusting for CYP2C19 *2/*3 alleles. PMID: 29407631
    3. PEAR1 methylation corresponded to variability in expression of ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC. PMID: 29614055
    4. PEAR1 rs12041331 polymorphism may influence ticagrelor pharmacodynamics PMID: 27937053
    5. DNA methylation at 4 different loci of PEAR1 during in vitro megakaryopoiesis, was studied. PMID: 27313330
    6. In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications PMID: 28449647
    7. PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel. PMID: 26962983
    8. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
    9. in a Chinese pedigree, SNP rs778026543, but not rs1952294 and rs822442, may be a susceptibility for pulmonary thromboembolism PMID: 28002340
    10. Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis. PMID: 26156496
    11. Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease. PMID: 26406321
    12. FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
    13. genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
    14. A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease. PMID: 25360888
    15. study suggests that PEAR1 is not a hypertension susceptibility gene in humans. PMID: 25541647
    16. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics PMID: 23859572
    17. additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified. PMID: 23704978
    18. A-allele carriers of rs12041331 in the platelet endothelial aggregation receptor-1 (PEAR1) gene were more likely to experience a cardiovascular event or death compared with GG homozygotes PMID: 23392654
    19. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. PMID: 23667054
    20. A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression. PMID: 21791418
    21. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
    22. PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts PMID: 15851471
    23. C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets PMID: 18511696
    24. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429868
    25. Observational study of gene-disease association. (HuGE Navigator) PMID: 18511696

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  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    MEGF family
  • 組織特異性：
    Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord
  • 數據庫鏈接：

    HGNC: 33631

    OMIM: 610278

    KEGG: hsa:375033

    STRING: 9606.ENSP00000292357

    UniGene: Hs.142003



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