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  4. PC (ATH3G10 Biosimilar) Recombinant Monoclonal Antibody

PC (ATH3G10 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA017511MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    PC (ATH3G10 Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物試劑，其核心成分為通過基因工程技術制備的重組單克隆抗體。該產品基于特定的抗體序列設計，采用重組DNA技術在適宜的表達系統中進行高效表達，并經過嚴格的純化工藝獲得高純度的抗體分子。 作為科研用試劑，該重組單克隆抗體可廣泛應用于生物化學、分子生物學、細胞生物學等研究領域。在實驗中，它可作為特異性識別工具，用于目標蛋白的檢測、定量分析某些實驗操作。其高度均一的分子結構和特異性結合能力，有助于提高實驗結果的準確性和可重復性，為科研人員提供可靠的研究支持。 該產品的研發和生產過程遵循嚴格的質量控制標準，確保抗體的生物學活性、純度及穩定性符合科研實驗的要求。在使用時，科研人員可根據具體實驗需求，選擇合適的稀釋比例和反應條件，以實現對目標分子的精準識別與分析。通過與目標抗原的特異性結合，該重組單克隆抗體能夠助力研究人員深入探索蛋白質功能、信號通路調控、疾病相關分子機制等科學問題，為生命科學領域的基礎研究和應用研究提供重要的工具支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    3G10 research-grade biosimilar; ATH3G10 research-grade biosimilar; IgG phosphorylcholine antibody research-grade biosimilar; PCmab research-grade biosimilar; PC-mAb research-grade biosimilar ;PC antibody; Pyruvate carboxylase, mitochondrial antibody; EC 6.4.1.1 antibody; Pyruvic carboxylase antibody; PCB antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PC protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
  • 基因功能參考文獻：
    1. PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. PMID: 27890529
    2. breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment. PMID: 27732858
    3. Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS signalosome. PMID: 26906558
    4. PC and PDH may be an important part of cellular adaptation to the IDH1 mutation and may serve as potential therapeutic targets PMID: 25243911
    5. These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. PMID: 25607840
    6. Increased PC expression is correlated with the malignant progression of GC, which might be a potential target for GC biotherapy. PMID: 23294723
    7. characterization of PC distal promoter PMID: 23383084
    8. PC protein is easily detectable by streptavidin blot and the presence of considerable amounts of PC in cultured human myotubes and in human muscle tissue was shown. PMID: 20807508
    9. IVS15+2-5delTAGG results in the retention of intron 15 during pre-mRNA splicing and frameshift mutations. PMID: 12112657
    10. expression and characterization of a variant by retroviral gene transfer PMID: 12437512
    11. 1 deficiency patient survived from neonatal lactic acidemia and shows an unusual subcortical leucodystrophic process. PMID: 16325442
    12. The crystal structures at 2.8-A resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC, is reported. PMID: 18297087
    13. Eight novel mutations were identified in PC from 8 pyruvate carboxylase deficiency patients. PMID: 18676167
    14. The activities of pyruvate carboxylase (PC) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
    15. Nine novel mutations of the PC gene, in five unrelated patients, are reported. PMID: 19306334

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  • 相關疾病：
    Pyruvate carboxylase deficiency (PC deficiency)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 數據庫鏈接：

    HGNC: 8636

    OMIM: 266150

    KEGG: hsa:5091

    STRING: 9606.ENSP00000377527

    UniGene: Hs.89890



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