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NPR1 (REGN-7544 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA016023MB2HU
  • 規格:
    ¥83486
  • 其他:

產品詳情

  • 產品描述:
    NPR1(REGN-7544 Biosimilar Antibody)重組單克隆抗體)是一種通過基因工程技術制備的生物制劑,專為科研用途設計。該產品以重組DNA技術為基礎,在哺乳動物細胞表達系統中進行高效表達,確保抗體分子的正確折疊與翻譯后修飾,從而維持其結構完整性和生物學活性。 作為單克隆抗體,NPR1具有高度均一性和靶向特異性,可特異性識別并結合其靶標分子,為生命科學研究提供可靠的工具。其生產過程嚴格遵循生物制藥級別的質量控制標準,通過多步純化工藝去除雜質,保證產品的高純度和低內毒素水平,滿足細胞培養、蛋白質相互作用分析、免疫檢測等多種實驗需求。 在科研應用中,NPR1可廣泛用于靶點驗證、信號通路研究、疾病模型構建等領域。例如,通過特異性結合靶蛋白,可探究其在生理或病理過程中的功能機制;在細胞實驗中,可用于檢測靶分子的表達水平或進行亞細胞定位分析;在動物實驗中,可作為工具抗體研究相關疾病的發病機制。 該產品僅用于科研目的,不用于臨床治療或診斷。其穩定的批次間一致性和明確的生物學活性,為科研人員提供了可重復的實驗結果保障,有助于推動免疫學、細胞生物學、分子生物學等領域的基礎研究和應用探索。
  • Uniprot No.:
  • 基因名:
  • 別名:
    REGN7544 research-grade biosimilar; REGN 7544 research-grade biosimilar ;NPR1 antibody; ANPRA antibody; Atrial natriuretic peptide receptor 1 antibody; EC 4.6.1.2 antibody; Atrial natriuretic peptide receptor type A antibody; ANP-A antibody; ANPR-A antibody; NPR-A antibody; Guanylate cyclase A antibody; GC-A antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human NPR1 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能:
    Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
  • 基因功能參考文獻:
    1. These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans. PMID: 28765884
    2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer. PMID: 27634171
    3. Data suggest that signaling via ANP/ANPR (atrial natriuretic factor/ANP receptor) in vascular endothelial cells activates PAK4 (p21-activated kinase 4) and CCM2 (cerebral cavernous malformation 2 protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP/ANPR signaling. PMID: 28432261
    4. After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP in HEK-293 cells. PMID: 26374856
    5. Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitivity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss. PMID: 26253614
    6. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation PMID: 25955817
    7. NPRA was detected in E11.5 cardiac progenitor cells. PMID: 25631869
    8. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator. PMID: 25117468
    9. High NPR1 expression is associated with esophageal squamous cell carcinomas. PMID: 24885858
    10. Molecular dynamics analysis indicated decreases in the values of Van der Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA/Vasonatrin peptide. PMID: 24699414
    11. ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB, as potent as their native ligands in receptor transfected cells. PMID: 23186809
    12. Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain. PMID: 22949736
    13. human ventricular cardiomyocytes express low levels of GC-A and GC-A in cardiomyocytes from failing human hearts is refractory to ANP stimulation. PMID: 22133375
    14. Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury. PMID: 22001395
    15. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity. PMID: 21366551
    16. Go6976 reduces GTP binding to the catalytic site of GC-A and GC-B and that ATP increases the magnitude of the inhibition. PMID: 21828054
    17. Midregional pro-A-type natriuretic peptide has a comparable accuracy to brain natriuretic peptide BNP for evaluation of cardiocirculatory exercise limitation. PMID: 20034689
    18. NPRA promotes prostate cancer development in part by regulating macrophage migration inhibitory factor PMID: 21586128
    19. review attempts to provide insights and to delineate the current concepts in the field of functional genomics and signaling of GC-A/NPRA in hypertension and cardiovascular disease states at the molecular level PMID: 21375691
    20. we identified and characterized new phosphorylation sites in GC-A and GC-B and provide the first evidence of phosphorylation sites within human guanylyl cyclases. PMID: 20977274
    21. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD PMID: 20529973
    22. kinetics of internalization, trafficking, and down-regulation of recombinant guanylyl cyclase/natriuretic peptide receptor-A (NPRA) PMID: 11704663
    23. unlikely that NPR1 is the same as the MCKD1 gene, mutations in which cause the adult form of medullary cystic kidney disease type 1; however, it is presently unknown whether it plays a disease modifying role PMID: 11851379
    24. This gene codes for natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. PMID: 12483301
    25. The "deletion 15129" variant might participate in the functional impairment of natriuretic peptide system defining and increased genetic susceptibility to hypertension. PMID: 12506509
    26. activation stabilizes a membrane-distal dimer interface PMID: 12547834
    27. Human dendritic cells, but not monocytes, express functional ANP receptor GC-A at both mRNA and protein levels. PMID: 12794112
    28. NPRA-PKG association may have a role in compartmentation of cGMP-mediated signaling and regulation of receptor sensitivity PMID: 12855709
    29. The novel Npr1 gene 3C variant and the Npr3 gene C(-55) allele are associated with hypertensive family history PMID: 12872042
    30. the M341I missense mutation is associated with risk of myocardial infarct (MI) and may be a genetic marker of MI PMID: 14646971
    31. NPR-A and NPR-B are desensitized in cells in which they are not internalized. PMID: 15459247
    32. discussion of experimental insights into the mechanisms that cells utilize in modulating the delivery and metabolic processing of ligand-bound NPRA into the cell interior [review] PMID: 15911067
    33. discussion of the functional significance of the promoter region of Npr1 gene and its transcriptional regulation [review] PMID: 15911069
    34. ATP does not activate NPRA and NPRB as has been repeatedly reported. Instead, ATP increases activity primarily by maintaining proper receptor phosphorylation status but also serves a previously unappreciated enzyme stabilizing function. PMID: 15911610
    35. interaction of atrial natriuretic peptide with natriuretic peptide receptor-A modulates the binding of ATP to the kinase homology domain PMID: 16262696
    36. NPR-A protein localized to cardiomyocytes, endocardial endothelial cells, and smooth muscle of intramyocardial vessels; downregulation in the density of NPR-A in heart and coronary was observed in artery of patients with ischemic heart disease PMID: 16778132
    37. Data suggest that natriuretic peptide receptor A (NPR-A) interacts with fibronectin to enhance brain natriuretic peptide (BNP) activation of cyclic GMP and that a small NPR-A-specific RGD peptide augments this action of BNP. PMID: 16986166
    38. In patients with Dukes stage C/D colorectal cancer, the Cox Proportional Hazard Model analysis demonstrated a significant association between increased patient survival and low expression of ITGB2 (p = 0.011) and NPR1 (p = 0.023) genes. PMID: 18306933
    39. Real-time PCR revealed that large adipocytes expressed higher mRNA levels of NPRA, and binding studies showed that large adipocytes expressed more NPR-A on the membrane than small adipocytes. PMID: 18383440
    40. The "4-minus" haplotype of the NPR-A receptor gene is associated with high NT-proBNP values and is a genetic determinant of the interindividual variability in the BNP system in healthy individuals but probably not in patients with cardiovascular disease. PMID: 18436476
    41. In the present study conducted in a homogeneous Hellenic population, no associations between Angiotensinogen,angiotensin-converting enzyme, and NPRA gene polymorphisms and hypertension were found. PMID: 19126660
    42. These results indicate that the ANP/GC-A system is involved in immune regulation through plasmacytoid dendritic cells in secondary lymphoid organs. PMID: 19563399

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  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 數據庫鏈接:

    HGNC: 7943

    OMIM: 108960

    KEGG: hsa:4881

    STRING: 9606.ENSP00000357669

    UniGene: Hs.490330



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