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  4. LILRB2 (Polzastobart Biosimilar) Recombinant Monoclonal Antibody

LILRB2 (Polzastobart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA839793MB7HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    LILRB2(Polzastobart Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發的高特異性生物試劑，其靶點為白細胞免疫球蛋白樣受體B2（LILRB2）。該受體屬于免疫球蛋白超家族成員，廣泛表達于免疫細胞表面，在免疫調節、炎癥反應及腫瘤微環境調控中發揮關鍵作用。 本產品通過重組DNA技術在哺乳動物細胞中表達，經多步純化工藝獲得高純度抗體，確保批次間一致性和實驗結果的可靠性。其抗原結合片段（Fab）可精準識別LILRB2胞外結構域，通過特異性結合實現對受體功能的調控研究。在實驗應用中，該抗體可用于檢測細胞表面LILRB2的表達水平，分析組織樣本中的受體分布，以及探究蛋白質相互作用等機制研究。 作為科研工具，LILRB2重組單克隆抗體為揭示免疫檢查點分子的生理病理功能提供了有力支持。研究人員可利用該抗體探索LILRB2在自身免疫性疾病、腫瘤免疫逃逸及感染性疾病中的作用機制，為開發新型治療策略提供理論依據。產品嚴格按照科研試劑標準生產，僅用于實驗室研究，不涉及臨床診斷或治療用途。 該抗體的研發與應用有助于推動免疫學及相關領域的基礎研究，為深入理解免疫調節網絡、發現潛在藥物靶點奠定實驗基礎。
  • Uniprot No.：
  • 基因名：
  • 別名：
    JTX8064 research-grade biosimilar; JTX-8064 research-grade biosimilar ;LILRB2 antibody; ILT4 antibody; LIR2 antibody; MIR10 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody; LIR-2 antibody; Leukocyte immunoglobulin-like receptor 2 antibody; CD85 antigen-like family member D antibody; Immunoglobulin-like transcript 4 antibody; ILT-4 antibody; Monocyte/macrophage immunoglobulin-like receptor 10 antibody; MIR-10 antibody; CD antigen CD85d antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human LILRB2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK)
  • 數據庫鏈接：

    HGNC: 6606

    OMIM: 604815

    STRING: 9606.ENSP00000375629

    UniGene: Hs.655652



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