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  4. LILRB2 (CHS-1000 Biosimilar) Recombinant Monoclonal Antibody

LILRB2 (CHS-1000 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA839793MB2HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    LILRB2 (CHS-1000 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發的生物試劑，旨在助力免疫調節機制及相關疾病研究。該抗體靶向白細胞免疫球蛋白樣受體B2（LILRB2），通過高特異性識別與結合該受體，為探索其在免疫抑制、炎癥反應及腫瘤微環境調控中的作用提供關鍵工具。 本產品采用重組DNA技術制備，經嚴格的質量控制確保批次間一致性與高純度。其抗原結合片段（Fab）可精準識別LILRB2胞外結構域，支持多種實驗應用，適用于細胞水平的受體表達分析、信號通路研究及受體-配體相互作用機制探討。 在科研場景中，該抗體可用于驗證LILRB2在巨噬細胞、樹突狀細胞等免疫細胞中的表達模式，揭示其在腫瘤免疫逃逸中的調控作用，或助力自身免疫性疾病的分子機制研究。其高度靶向性減少了非特異性結合干擾，為獲取可靠實驗數據提供保障。 產品嚴格限定于實驗室研究使用，不用于臨床診斷或治療。使用時需結合相關陽性對照與實驗方案優化，以確保研究結果的科學性與可重復性。通過提供特異性分子工具，該抗體為深入解析LILRB2介導的免疫調節網絡及開發潛在治療靶點奠定基礎。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CHS 1000 research-grade biosimilar; CHS-1000 research-grade biosimilar ;LILRB2 antibody; ILT4 antibody; LIR2 antibody; MIR10 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody; LIR-2 antibody; Leukocyte immunoglobulin-like receptor 2 antibody; CD85 antigen-like family member D antibody; Immunoglobulin-like transcript 4 antibody; ILT-4 antibody; Monocyte/macrophage immunoglobulin-like receptor 10 antibody; MIR-10 antibody; CD antigen CD85d antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human LILRB2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK)
  • 數據庫鏈接：

    HGNC: 6606

    OMIM: 604815

    STRING: 9606.ENSP00000375629

    UniGene: Hs.655652



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