KLRK1 (Tesnatilimab Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA012474MB1HU
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規格:¥83486
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其他:
產品詳情
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Uniprot No.:
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基因名:
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別名:ANTI-NKG2D research-grade biosimilar; IPH-2301 research-grade biosimilar; IPH-23XX research-grade biosimilar; JNJ-4500 research-grade biosimilar; JNJ-64304500 research-grade biosimilar; NN-8555 research-grade biosimilar; NNC-0142-0000-0002 research-grade biosimilar; NNC-0142-0002 research-grade biosimilar; NNC-0142-002 research-grade biosimilar; NNC142-0002 research-grade biosimilar; KLRK1 antibody; D12S2489E antibody; NKG2D antibody;NKG2-D type II integral membrane protein antibody; Killer cell lectin-like receptor subfamily K member 1 antibody; NK cell receptor D antibody; NKG2-D-activating NK receptor antibody; CD antigen CD314 antibody
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反應種屬:Human
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免疫原:Recombinant Human KLRK1 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產品
靶點詳情
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功能:Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
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亞細胞定位:Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
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組織特異性:Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
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數據庫鏈接:
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